naa a22 4500 510779514 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11892-013-0372-1 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0372-1 Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis [Elektronische Daten] [Anisha Gupte, Christopher Lyon, Willa Hsueh] Tissue oxidative stress is a common hallmark of atherosclerosis and non-alcoholic steatohepatitis (NASH), 2 conditions linked epidemiologically and pathophysiologically. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the master regulator of inducible antioxidant responses, that can attenuate cellular injury from oxidative stress induced by obesity and other redox insults. Nrf2 expression and activation is reduced in mouse and human vessels that harbor accelerated atherosclerosis and in livers with histologic criteria of NASH. Systemic antioxidants have thus been attractive therapeutic targets, but clinical trials have been largely unsuccessful in improving cardiovascular health. Macrophage-selective Nrf2 activation may, however, provide an approach to reduce vascular and hepatocyte injury without the complications of systemic antioxidants, since macrophages play key roles in the development and progression of both atherosclerosis and NASH. In this article, we review the common mechanisms of oxidative stress and inflammation in atherosclerosis and NASH, and discuss the role of Nrf2 in vascular and hepatocyte protection. Springer Science+Business Media New York, 2013 Nrf2 nationallicence Oxidative stress nationallicence Atherosclerosis nationallicence Nonalcoholic steatohepatitis nationallicence NASH nationallicence Gupte Anisha The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut Lyon Christopher The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut Hsueh Willa The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut Current Diabetes Reports Current Science Inc. 13/3(2013-06-01), 362-371 1534-4827 13:3<362 2013 13 11892 https://doi.org/10.1007/s11892-013-0372-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0372-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupte Anisha The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Lyon Christopher The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Hsueh Willa The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research in The Methodist Hospital Research Institute, Weill Cornell Medical College, R8-111, 6670 Bertner Ave, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/3(2013-06-01), 362-371 1534-4827 13:3<362 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer