naa a22 4500 510779522 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11892-013-0368-x doi (NATIONALLICENCE)springer-10.1007/s11892-013-0368-x Do Statins Cause Diabetes? [Elektronische Daten] [Mark Goldstein, Luca Mascitelli] A wealth of evidence has established that cholesterol-lowering statin drugs, widely used for the prevention of cardiovascular disease, do increase the risk of new-onset diabetes, possibly by impairing pancreatic beta cell function and decreasing peripheral insulin sensitivity. Groups at particular risk include the elderly, women, and Asians. The diabetogenic effect of statins appear directly related to statin dose and the degree of attained cholesterol lowering. Statins can cause hyperinsulinemia even in the absence of hyperglycemia and the potential mitogenic effects and implications of prolonged hyperinsulinemia are discussed. Suggestions are made as to how physicians might avert the hyperinsulinemic and diabetogenic effects of statin therapy in clinical practice, and modulate the detrimental effects of these drugs on exercise performance. Finally, long-term studies are needed to determine if the deleterious hyperinsulinemic and diabetogenic effects of statin therapy undermine the beneficial cardiovascular disease risk outcomes in various segments of the population. Springer Science+Business Media New York, 2013 Statins nationallicence Diabetes nationallicence Prediabetes nationallicence Hyperinsulinemia nationallicence Insulin resistance nationallicence Mitochondrial dysfunction nationallicence Cancer nationallicence Goldstein Mark NCH Healthcare Group, 1845 Veterans Park Drive, Suite 110, 34109, Naples, FL, USA aut Mascitelli Luca Comando Brigata Alpina "Julia”, Medical Service, 8 Via S. Agostino, 33100, Udine, Italy aut Current Diabetes Reports Current Science Inc. 13/3(2013-06-01), 381-390 1534-4827 13:3<381 2013 13 11892 https://doi.org/10.1007/s11892-013-0368-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0368-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldstein Mark NCH Healthcare Group, 1845 Veterans Park Drive, Suite 110, 34109, Naples, FL, USA aut NATIONALLICENCE 700 1- Mascitelli Luca Comando Brigata Alpina "Julia”, Medical Service, 8 Via S. Agostino, 33100, Udine, Italy aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/3(2013-06-01), 381-390 1534-4827 13:3<381 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer