naa a22 4500 510779549 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11892-013-0375-y doi (NATIONALLICENCE)springer-10.1007/s11892-013-0375-y Diabetes Mellitus and Inflammation [Elektronische Daten] [Eric Lontchi-Yimagou, Eugene Sobngwi, Tandi Matsha, Andre Kengne] Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications. Springer Science+Business Media New York, 2013 Diabetes mellitus nationallicence Inflammation nationallicence Biomarkers nationallicence Adipocytes nationallicence Cytokines nationallicence Adipokines nationallicence Interleukin nationallicence Lontchi-Yimagou Eric Laboratory for Molecular and Metabolic Diseases, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon aut Sobngwi Eugene National Obesity Center, Yaounde Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon aut Matsha Tandi Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa aut Kengne Andre South African Medical Research Council & University of Cape Town, Tygerberg, PO Box 19070, 7505, Cape Town, South Africa aut Current Diabetes Reports Current Science Inc. 13/3(2013-06-01), 435-444 1534-4827 13:3<435 2013 13 11892 https://doi.org/10.1007/s11892-013-0375-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0375-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lontchi-Yimagou Eric Laboratory for Molecular and Metabolic Diseases, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon aut NATIONALLICENCE 700 1- Sobngwi Eugene National Obesity Center, Yaounde Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon aut NATIONALLICENCE 700 1- Matsha Tandi Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa aut NATIONALLICENCE 700 1- Kengne Andre South African Medical Research Council & University of Cape Town, Tygerberg, PO Box 19070, 7505, Cape Town, South Africa aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/3(2013-06-01), 435-444 1534-4827 13:3<435 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer