naa a22 4500 510779611 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11892-013-0367-y doi (NATIONALLICENCE)springer-10.1007/s11892-013-0367-y Diabetes Mellitus and Periodontal Diseases [Elektronische Daten] [Corneliu Sima, Michael Glogauer] A bidirectional relationship between diabetes mellitus (DM) and periodontal diseases (PDs) has been established. It is estimated that patients with poorly controlled DM are 3 times more likely to develop chronic PD compared with normoglycemic individuals despite similar composition in subgingival biofilms. Furthermore, these patients present with increased severity and rapid progression of attachment loss around teeth resulting in edentulism. Treatment of PD results in a modest but significant improvement in glycemic control in patients with DM reflected by a 0.4% reduction in HbA1cglycated hemoglobin levels. Compelling evidence from in vitro and animal studies supports a plausible biological explanation for the relationship between the 2 conditions centered on systemic low-grade inflammation. However, the limited number of comparable large randomized clinical trials is reflected in the limited specific guidelines offered by the international organizations for DM and PD regarding the management of the 2 diseases in an individual. Springer Science+Business Media New York, 2013 Diabetes mellitus nationallicence Periodontal diseases nationallicence Inflammation nationallicence Glycemic control nationallicence HbA1c nationallicence Sima Corneliu Matrix Dynamics Group, Room 221 Fitzgerald Building, 150 College Street, M5S 3E2, Toronto, Ontario, Canada aut Glogauer Michael Matrix Dynamics Group, Room 221 Fitzgerald Building, 150 College Street, M5S 3E2, Toronto, Ontario, Canada aut Current Diabetes Reports Current Science Inc. 13/3(2013-06-01), 445-452 1534-4827 13:3<445 2013 13 11892 https://doi.org/10.1007/s11892-013-0367-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0367-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sima Corneliu Matrix Dynamics Group, Room 221 Fitzgerald Building, 150 College Street, M5S 3E2, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Glogauer Michael Matrix Dynamics Group, Room 221 Fitzgerald Building, 150 College Street, M5S 3E2, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/3(2013-06-01), 445-452 1534-4827 13:3<445 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer