naa a22 4500 510779638 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11892-013-0376-x doi (NATIONALLICENCE)springer-10.1007/s11892-013-0376-x Diabetes Mellitus and Osteoporosis [Elektronische Daten] [Robert Sealand, Christie Razavi, Robert Adler] Diabetes mellitus (particularly type 2) and osteoporosis are two very common disorders, and both are increasing in prevalence. Adolescents with type 1 diabetes mellitus may not reach potential peak bone mass, putting them at greater fracture risk. In adults with type 2 diabetes, fracture risk is increased and is not explained by the bone mineral density measured by dual-energy X-ray absorptiometry, still considered the gold standard predictor of fracture. In this review, we explore potential mechanisms behind the increased fracture risk that occurs in patients with diabetes, even those with increased bone mineral density. One potential link between diabetes and bone is the osteoblast-produced factor, osteocalcin. It remains to be established whether osteocalcin reflects or affects the connection between bone and glucose metabolism. Several other potential mediators of the effects of diabetes on bone are discussed. Springer Science+Business Media New York (outside the USA), 2013 Diabetes mellitus nationallicence Type 1 diabetes mellitus nationallicence Type 2 diabetes mellitus nationallicence Osteoporosis nationallicence Fracture nationallicence Obesity nationallicence Bone mineral density nationallicence Dual energy X-ray absorptiometry nationallicence Osteocalcin nationallicence Sealand Robert Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut Razavi Christie Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut Adler Robert Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut Current Diabetes Reports Current Science Inc. 13/3(2013-06-01), 411-418 1534-4827 13:3<411 2013 13 11892 https://doi.org/10.1007/s11892-013-0376-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0376-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sealand Robert Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut NATIONALLICENCE 700 1- Razavi Christie Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut NATIONALLICENCE 700 1- Adler Robert Endocrinology (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, 23249, Richmond, VA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/3(2013-06-01), 411-418 1534-4827 13:3<411 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer