naa a22 4500 510779654 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0381-0 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0381-0 Uric Acid Lowering to Prevent Kidney Function Loss in Diabetes: The Preventing Early Renal Function Loss (PERL) Allopurinol Study [Elektronische Daten] [David Maahs, Luiza Caramori, David Cherney, Andrzej Galecki, Chuanyun Gao, Diana Jalal, Bruce Perkins, Rodica Pop-Busui, Peter Rossing, Michael Mauer, Alessandro Doria] Diabetic kidney disease causes significant morbidity and mortality among people with type 1 diabetes (T1D). Intensive glucose and blood pressure control have thus far failed to adequately curb this problem and therefore a major need for novel treatment approaches exists. Multiple observations link serum uric acid levels to kidney disease development and progression in diabetes and strongly argue that uric acid lowering should be tested as one such novel intervention. A pilot of such a trial, using allopurinol, is currently being conducted by the Preventing Early Renal Function Loss (PERL) Consortium. Although the PERL trial targets T1D individuals at highest risk of kidney function decline, the use of allopurinol as a renoprotective agent may also be relevant to a larger segment of the population with diabetes. As allopurinol is inexpensive and safe, it could be cost-effective even for relatively low-risk patients, pending the completion of appropriate trials at earlier stages. Springer Science+Business Media New York, 2013 Uric acid nationallicence Kidney disease nationallicence Diabetes nationallicence Diabetic kidney disease nationallicence Glomerular filtration rate nationallicence Allopurinol nationallicence Diabetic nephropathy nationallicence Randomized clinical trial nationallicence Type 1 diabetes nationallicence PERL trial nationallicence Maahs David Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA aut Caramori Luiza Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut Cherney David Department of Medicine and Division of Nephrology, University of Toronto, Toronto, ON, Canada aut Galecki Andrzej Division of Geriatrics/Institute of Gerontology, Medical School, and Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA aut Gao Chuanyun Joslin Clinic, Joslin Diabetes Center, Boston, MA, USA aut Jalal Diana Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA aut Perkins Bruce Department of Medicine and Division of Endocrinology, University of Toronto, Toronto, ON, Canada aut Pop-Busui Rodica Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA aut Rossing Peter Steno Diabetes Center, Gentofte, Denmark aut Mauer Michael Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut Doria Alessandro Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, 02215, Boston, MA, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 550-559 1534-4827 13:4<550 2013 13 11892 https://doi.org/10.1007/s11892-013-0381-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0381-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maahs David Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA aut NATIONALLICENCE 700 1- Caramori Luiza Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Cherney David Department of Medicine and Division of Nephrology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Galecki Andrzej Division of Geriatrics/Institute of Gerontology, Medical School, and Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Gao Chuanyun Joslin Clinic, Joslin Diabetes Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Jalal Diana Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA aut NATIONALLICENCE 700 1- Perkins Bruce Department of Medicine and Division of Endocrinology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Pop-Busui Rodica Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Rossing Peter Steno Diabetes Center, Gentofte, Denmark aut NATIONALLICENCE 700 1- Mauer Michael Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Doria Alessandro Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, 02215, Boston, MA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 550-559 1534-4827 13:4<550 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer