naa a22 4500 510779662 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0382-z doi (NATIONALLICENCE)springer-10.1007/s11892-013-0382-z Soluble Mediators of Diabetic Macular Edema: The Diagnostic Role of Aqueous VEGF and Cytokine Levels in Diabetic Macular Edema [Elektronische Daten] [Leah Owen, M. Hartnett] Diabetic macular edema (DME) is a significant cause of vision loss and represents an important clinical and public health problem. It is characterized by breakdown of the blood retinal barrier with fluid accumulation in the sub-retinal and intra-retinal spaces. Although several hypotheses exist for the causes of diabetic macular edema, specific molecular mechanisms remain unclear. Current thinking includes the role of vascular endothelial growth factor (VEGF) and inflammatory cytokines in vascular permeability. We review studies showing a relationship between elevated aqueous VEGF, monocyte chemoattractant protein -1, interleukin 6, or interleukin 8 in association with DME and as predictors of DME. The presence of mediators in both the angiogenesis and inflammatory pathways data suggest a multifactorial model for the development of DME. Further studies targeting individual cytokine activity will be important to our understanding of the pathogenesis and treatment. Springer Science+Business Media New York, 2013 Diabetes mellitus nationallicence Macular edema nationallicence VEGF nationallicence Diabetic retinopathy nationallicence Cytokines nationallicence Owen Leah Department Of Ophthalmology, Moran Eye Center, University of Utah, 65 North Mario Capecchi Dr, 84132, Salt Lake City, UT, USA aut Hartnett M. Department Of Ophthalmology, Moran Eye Center, University of Utah, 65 North Mario Capecchi Dr, 84132, Salt Lake City, UT, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 476-480 1534-4827 13:4<476 2013 13 11892 https://doi.org/10.1007/s11892-013-0382-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0382-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Owen Leah Department Of Ophthalmology, Moran Eye Center, University of Utah, 65 North Mario Capecchi Dr, 84132, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Hartnett M. Department Of Ophthalmology, Moran Eye Center, University of Utah, 65 North Mario Capecchi Dr, 84132, Salt Lake City, UT, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 476-480 1534-4827 13:4<476 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer