naa a22 4500 510779697 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0395-7 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0395-7 Temporal Profile of Diabetic Nephropathy Pathologic Changes [Elektronische Daten] [Cecilia Ponchiardi, Michael Mauer, Behzad Najafian] Diabetic nephropathy, by far, is the most common cause of end stage renal disease in the US and many other countries. In type 1 diabetes, the natural history of diabetic nephropathy is tightly linked to evolution of classic lesions of the disease, namely glomerular basement membrane thickening, increased mesangial matrix, and reduced glomerular filtration surface density. These lesions progress in parallel and correlate with increased albumin excretion rate and reduced glomerular filtration rate across a wide range of renal function. In fact, the vast majority of the variances of albumin excretion and glomerular filtration rates can be explained by these glomerular lesions alone in type 1 diabetic patients. Although, classic lesions of diabetic nephropathy, indistinguishable from those of type 1 diabetes, also occur in type 2 diabetes, renal lesions are more heterogeneous in type 2 diabetic patients with some patients developing more advanced vascular or chronic tubulointerstitial lesions than diabetic glomerulopathy. More research biopsy longitudinal studies, especially in type 2 diabetic patients, are needed to better understand various pathways of renal injury in diabetic nephropathy. Springer Science+Business Media New York, 2013 Diabetes nationallicence Type 1 diabetes nationallicence Type 2 diabetes nationallicence Diabetic nephropathy nationallicence Structural-functional relationships nationallicence Ponchiardi Cecilia Department of Pathology, University of Washington, 1959 NE Pacific St, Box 356100, 98195, Seattle, WA, USA aut Mauer Michael Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut Najafian Behzad Department of Pathology, University of Washington, 1959 NE Pacific St, Box 356100, 98195, Seattle, WA, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 592-599 1534-4827 13:4<592 2013 13 11892 https://doi.org/10.1007/s11892-013-0395-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0395-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ponchiardi Cecilia Department of Pathology, University of Washington, 1959 NE Pacific St, Box 356100, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Mauer Michael Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Najafian Behzad Department of Pathology, University of Washington, 1959 NE Pacific St, Box 356100, 98195, Seattle, WA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 592-599 1534-4827 13:4<592 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer