naa a22 4500 510779700 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0387-7 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0387-7 Painful and Painless Diabetic Neuropathy: One Disease or Two? [Elektronische Daten] [Vincenza Spallone, Carla Greco] Painful diabetic polyneuropathy (PDPN) is generally considered a variant of diabetic polyneuropathy (DPN) but the identification of distinctive aspects that characterize painful compared with painless DPN has however been addressed in many studies, mainly with the purpose of better understanding the mechanisms of neuropathic pain in the scenario of peripheral nerve damage of DPN, of determining risk markers for pain development, and also of recognizing who might respond to treatments. This review is aimed at examining available literature dealing with the issue of similarities and differences between painful and painless DPN in an attempt to respond to the question of whether painful and painless DPN are the same disease or not and to address the conundrum of why some people develop the insensate variety of DPN whilst others experience distressing pain. Thus, from the perspective of comparing painful with painless forms of DPN, this review considers the clinical correlates of PDPN, its distinctive framework of symptoms, signs, and nerve functional and structural abnormalities, the question of large and small fiber involvement, the peripheral pain mechanisms, the central processing of pain and some new insights into the pathogenesis of pain in peripheral polyneuropathies and PDPN. Springer Science+Business Media New York, 2013 Painful nationallicence Painless nationallicence Diabetic neuropathy nationallicence Neuropathic pain nationallicence Risk factors nationallicence Biomarkers nationallicence Predictors nationallicence Autonomic neuropathy nationallicence Small fiber neuropathy nationallicence Epidemiology nationallicence Pain mechanisms nationallicence Genetics nationallicence Central plasticity nationallicence Inflammation nationallicence Painful neuropathy nationallicence Painless neuropathy nationallicence Spallone Vincenza Endocrinology, Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Greco Carla Endocrinology, Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 533-549 1534-4827 13:4<533 2013 13 11892 https://doi.org/10.1007/s11892-013-0387-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0387-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spallone Vincenza Endocrinology, Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Greco Carla Endocrinology, Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 533-549 1534-4827 13:4<533 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer