naa a22 4500 510779719 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0396-6 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0396-6 Freeman Roy Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, One Deaconess Road, 02215, Boston, MA, USA aut New and Developing Drugs for the Treatment of Neuropathic Pain in Diabetes [Elektronische Daten] [Roy Freeman] A number of agents from diverse pharmacological classes are used to treat neuropathic pain associated with diabetic peripheral neuropathy. Only three of these have regulatory approval for this indication in the U.S. In this focused article, I will discuss selected drugs, newly approved or in development, to treat neuropathic pain in patients with diabetic neuropathy. These will include agonists and antagonists of the transient receptor potential channels, a family of receptor proteins that play a role in the transduction of physical stress; sodium channel isoform specific antagonists; a recently approved dual-action opioid receptor agonist-norepinephrine reuptake inhibitor; gene therapy for neuropathic pain; and anti-nerve growth factor molecules. Mechanisms of action, preclinical supporting data, clinical trial evidence, and adverse effects will be reviewed. Springer Science+Business Media New York, 2013 Neuropathic pain nationallicence Diabetic peripheral neuropathy nationallicence TRPV1 nationallicence TRPA1capsaicin nationallicence Sodium channel antagonists nationallicence NaV1.7 nationallicence Anti-NGF antibodies nationallicence Gene therapy nationallicence Tapentadol nationallicence Diabetes nationallicence Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 500-508 1534-4827 13:4<500 2013 13 11892 https://doi.org/10.1007/s11892-013-0396-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0396-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Freeman Roy Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, One Deaconess Road, 02215, Boston, MA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 500-508 1534-4827 13:4<500 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer