naa a22 4500 510779743 CHVBK 20180411083242.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0386-8 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0386-8 Emerging Roles for miRNAs in the Development, Diagnosis, and Treatment of Diabetic Nephropathy [Elektronische Daten] [Johanna DiStefano, Matthew Taila, M. Alvarez] Although the causes of diabetic nephropathy are not yet fully known, emerging evidence suggests a role for epigenetic factors in the development of the disease. In particular, microRNAs (miRNAs) are becoming recognized as important mediators of biological processes relevant to diabetic nephropathy. Until recently, investigations of miRNAs in the development of diabetic nephropathy have remained relatively limited; however, the number of reports identifying potential new candidates and mechanisms of impact is presently expanding at a rapid pace. This review seeks to summarize these recent findings, focusing on new candidates and/or novel mechanisms, including the intersection between genetic variation and miRNA function in modulating disease expression, emerging in the field. We also review the latest advances in the diagnostic and therapeutic potential of miRNAs in the treatment of diabetic nephropathy. Springer Science+Business Media New York, 2013 MiRNAs nationallicence Diabetic nephropathy nationallicence Renal fibrosis nationallicence End-stage renal disease nationallicence Chronic kidney disease nationallicence Biomarkers nationallicence Urinary exosomes nationallicence Transforming growth factor-β nationallicence Locked nucleic acid (LNA) nationallicence Epigenetics nationallicence miR-192 nationallicence miR-21 nationallicence miR-29 nationallicence miR-1207-5p nationallicence Urine nationallicence DiStefano Johanna Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut Taila Matthew Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut Alvarez M. Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 582-591 1534-4827 13:4<582 2013 13 11892 https://doi.org/10.1007/s11892-013-0386-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0386-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DiStefano Johanna Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Taila Matthew Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Alvarez M. Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, 445 North Fifth Street, 85004, Phoenix, AZ, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 582-591 1534-4827 13:4<582 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer