naa a22 4500 51077976X CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0385-9 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0385-9 Novel Biomarkers for the Progression of Diabetic Nephropathy: Soluble TNF Receptors [Elektronische Daten] [Tomohito Gohda, Yasuhiko Tomino] Despite 2 decades of advances in therapy of diabetic patients, the prevalence of diabetic nephropathy among patients with diabetes has not decreased. However, large-scale multicenter studies have achieved great success in terms of the reduction of albuminuria, suggesting that albuminuria might not be an accurate surrogate marker for slowing the rate of renal function decline. It is important to be able to identify individuals at high risk for renal function decline, or ultimately, end-stage kidney disease (ESKD) and its associated cardiovascular disease (CVD). More sensitive early biomarkers, other than albuminuria and the estimated glomerular filtration rate (eGFR), should be required. Recently, serum concentrations of soluble tumor necrosis factor (TNF), receptor 1 (TNFR1), and TNFR2 have predicted future GFR loss and ESKD in patients of a wide variety of stages and both types of diabetes. Longitudinal interventional studies are needed to validate these biomarkers in a broad range of populations prior to implementation in routine diabetes management. Springer Science+Business Media New York, 2013 TNF-α nationallicence TNF receptor 1 (TNFR1) nationallicence TNF receptor 2 (TNFR2) nationallicence Inflammation nationallicence Biomarker nationallicence Chronic kidney disease (CKD) nationallicence Diabetes nationallicence Diabetic nephropathy nationallicence Gohda Tomohito Division of Nephrology, Department of Internal Medicine, Juntendo University, Faculty of Medicine, Hongo 2-1-1, 113-8421, Bunkyo-ku, Tokyo, Japan aut Tomino Yasuhiko Division of Nephrology, Department of Internal Medicine, Juntendo University, Faculty of Medicine, Hongo 2-1-1, 113-8421, Bunkyo-ku, Tokyo, Japan aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 560-566 1534-4827 13:4<560 2013 13 11892 https://doi.org/10.1007/s11892-013-0385-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0385-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gohda Tomohito Division of Nephrology, Department of Internal Medicine, Juntendo University, Faculty of Medicine, Hongo 2-1-1, 113-8421, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Tomino Yasuhiko Division of Nephrology, Department of Internal Medicine, Juntendo University, Faculty of Medicine, Hongo 2-1-1, 113-8421, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 560-566 1534-4827 13:4<560 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer