naa a22 4500 510779778 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0383-y doi (NATIONALLICENCE)springer-10.1007/s11892-013-0383-y Glycemic Memories and the Epigenetic Component of Diabetic Nephropathy [Elektronische Daten] [Samuel Keating, Assam El-Osta] A strong case for the deregulation of epigenetic chromatin modifications in the development and progression of various chronic complications of diabetes has emerged from recent experimental observations. Clinical trials of type 1 and type 2 diabetes patients highlight the importance of early and intensive treatment and the prolonged damage of hyperglycemia on organs such as the kidney. The functional relationship between the regulation of chromatin architecture and persistent gene expression changes conferred by prior hyperglycemia represents an important avenue of investigation for explaining diabetic nephropathy. While several studies implicate epigenetic changes at the chromatin template in the deregulated gene expression associated with diabetic nephropathy, the molecular determinants of metabolic memory in renal cells remain poorly understood. There is now strong evidence from experimental animals and cell culture of persistent glucose-driven changes in vascular endothelial gene expression that may also have relevance for the microvasculature of the kidney. Exploration of epigenetic mechanisms underlying the hyperglycemic cue mediating persistent transcriptional changes in renal cells holds novel therapeutic potential for diabetic nephropathy. Springer Science+Business Media New York, 2013 Glycemic memory nationallicence Metabolic memory nationallicence Epigenetic nationallicence Diabetic nephropathy nationallicence Diabetic complications nationallicence Chromatin modifications nationallicence Keating Samuel Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3004, Melbourne, Victoria, Australia aut El-Osta Assam Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3004, Melbourne, Victoria, Australia aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 574-581 1534-4827 13:4<574 2013 13 11892 https://doi.org/10.1007/s11892-013-0383-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0383-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Keating Samuel Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3004, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- El-Osta Assam Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3004, Melbourne, Victoria, Australia aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 574-581 1534-4827 13:4<574 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer