naa a22 4500 510779786 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0384-x doi (NATIONALLICENCE)springer-10.1007/s11892-013-0384-x Antioxidants and Diabetic Retinopathy [Elektronische Daten] [Michael Williams, Ruth Hogg, Usha Chakravarthy] The biochemical perturbations in diabetes mellitus (DM) create the conditions for the production of free radicals, the consequence of which is increased oxidative stress. Evidence has accrued over the past 2 decades that suggests that oxidative stress is an important pathogenetic factor in the development of diabetic retinopathy (DR). Experimental data show that the use of strategies that ameliorate oxidative stress can prevent and retard the development of DR in the animal model. Clinical observations also suggest that reducing oxidative stress may help to reverse pathological manifestations of DR. The present article constitutes an examination of the role of antioxidants in the management of DR and the current state of clinically relevant knowledge. Springer Science+Business Media New York, 2013 Oxidation nationallicence Antioxidants nationallicence Reactive oxygen species nationallicence Retinopathy nationallicence Diabetes nationallicence Williams Michael Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK aut Hogg Ruth Centre for Vision and Vascular Science, Queen's University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK aut Chakravarthy Usha Centre for Vision and Vascular Science, Queen's University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 481-487 1534-4827 13:4<481 2013 13 11892 https://doi.org/10.1007/s11892-013-0384-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0384-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Williams Michael Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Hogg Ruth Centre for Vision and Vascular Science, Queen's University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Chakravarthy Usha Centre for Vision and Vascular Science, Queen's University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 481-487 1534-4827 13:4<481 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer