naa a22 4500 510779794 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0390-z doi (NATIONALLICENCE)springer-10.1007/s11892-013-0390-z Corneal Confocal Microscopy: A New Technique for Early Detection of Diabetic Neuropathy [Elektronische Daten] [N. Papanas, D. Ziegler] Corneal confocal microscopy (CCM) is a noninvasive method for the study of human cornea in vivo. It has increasingly been used to assess the morphology of the sub-basal corneal nerve plexus. CCM has good reproducibility and may contribute to the early diagnosis of diabetic polyneuropathy. It may also be useful to document favorable changes in nerve fiber structure early after therapeutic intervention. Corneal nerve pathology is more pronounced in patients with diabetic polyneuropathy and is associated with its clinical severity. The sensitivity and specificity of CCM for the diagnosis of polyneuropathy is moderate to high. CCM now merits further use in large longitudinal studies to provide more information on the natural history of diabetic neuropathy and effects of treatment. Moreover, there is a need for a larger normative database. Finally, technical progress is expected to enable visualization of larger corneal areas and improve nerve fiber quantification, increasing diagnostic accuracy. Springer Science+Business Media New York, 2013 Complications nationallicence Corneal confocal microscopy nationallicence Diabetes mellitus nationallicence Diabetic neuropathy nationallicence Diagnosis nationallicence Papanas N. Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany aut Ziegler D. Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 488-499 1534-4827 13:4<488 2013 13 11892 https://doi.org/10.1007/s11892-013-0390-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0390-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papanas N. Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Ziegler D. Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 488-499 1534-4827 13:4<488 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer