naa a22 4500 510779808 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11892-013-0394-8 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0394-8 Magnetic Resonance Imaging of the Central Nervous System in Diabetic Neuropathy [Elektronische Daten] [Iain Wilkinson, Dinesh Selvarajah, Marni Greig, Pallai Shillo, Elaine Boland, Rajiv Gandhi, Solomon Tesfaye] Diabetic ‘peripheral' neuropathy (DPN) is one of the common sequelae to the development of both type-1 and type-2 diabetes mellitus. Neuropathy has a major negative impact on quality of life. Abnormalities in both peripheral vasculature and nerve function are well documented and, in addition, evidence is emerging regarding changes within the central nervous system (CNS) that are concomitant with the presence of DPN. The often-resistant nature of DPN to medical treatment highlights the need to understand the role of the CNS in neuropathic symptomatology and progression, as this may modulate therapeutic approaches. Advanced neuroimaging techniques, especially those that can provide quantitative measures of structure and function, can provide objective markers of CNS status. With that comes great potential for not only furthering our understanding of involvement of the CNS in neuropathic etiology but also most importantly aiding the development of new and more effective, targeted, analgesic interventions. Springer Science+Business Media New York, 2013 Diabetic peripheral neuropathy nationallicence Neuroimaging nationallicence Magnetic resonance imaging nationallicence Brain nationallicence Spine nationallicence Central nervous system nationallicence Wilkinson Iain Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut Selvarajah Dinesh Academic Diabetes, Endocrinology & Metabolism, University of Sheffield, Sheffield, UK aut Greig Marni Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut Shillo Pallai Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut Boland Elaine Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut Gandhi Rajiv Diabetes Research, Royal Hallamshire Hospital, Sheffield, UK aut Tesfaye Solomon Diabetes Research, Royal Hallamshire Hospital, Sheffield, UK aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 509-516 1534-4827 13:4<509 2013 13 11892 https://doi.org/10.1007/s11892-013-0394-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0394-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilkinson Iain Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Selvarajah Dinesh Academic Diabetes, Endocrinology & Metabolism, University of Sheffield, Sheffield, UK aut NATIONALLICENCE 700 1- Greig Marni Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Shillo Pallai Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Boland Elaine Academic Radiology, University of Sheffield, C-Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Gandhi Rajiv Diabetes Research, Royal Hallamshire Hospital, Sheffield, UK aut NATIONALLICENCE 700 1- Tesfaye Solomon Diabetes Research, Royal Hallamshire Hospital, Sheffield, UK aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/4(2013-08-01), 509-516 1534-4827 13:4<509 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer