naa a22 4500 510779832 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0401-0 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0401-0 Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival [Elektronische Daten] [Antonio Citro, Elisa Cantarelli, Lorenzo Piemonti] Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as "master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Springer Science+Business Media New York, 2013 Islet   transplantation nationallicence Early   innate   immune   events nationallicence Chemokines nationallicence Danger signals nationallicence Polymorphonuclear cells nationallicence Instant  blood  mediated  inflammatory  reaction nationallicence Anti-inflammatory  strategies nationallicence Islet  engraftment nationallicence Survival nationallicence Citro Antonio Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut Cantarelli Elisa Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut Piemonti Lorenzo Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 733-744 1534-4827 13:5<733 2013 13 11892 https://doi.org/10.1007/s11892-013-0401-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0401-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Citro Antonio Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Cantarelli Elisa Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Piemonti Lorenzo Beta Cell Biology Unit, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 733-744 1534-4827 13:5<733 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer