naa a22 4500 510779840 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0403-y doi (NATIONALLICENCE)springer-10.1007/s11892-013-0403-y Haumaitre Cecile CNRS UMR 7622, Université Pierre et Marie Curie, INSERM U969, 9 quai Saint Bernard, 75005, Paris, France aut Epigenetic Regulation of Pancreatic Islets [Elektronische Daten] [Cecile Haumaitre] Epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNA expression, contribute to regulate islet cell development and function. Indeed, epigenetic mechanisms were recently shown to be involved in the control of endocrine cell fate decision, islet differentiation, β-cell identity, proliferation, and mature function. Epigenetic mechanisms can also contribute to the pathogenesis of complex diseases. Emerging knowledge regarding epigenetic mechanisms suggest that they may be involved in β-cell dysfunction and pathogenesis of diabetes. Epigenetic mechanisms could predispose to the diabetic phenotype such as decline of β-cell proliferation ability and β-cell failure, and account for complications associated with diabetes. Better understanding of epigenetic landscapes of islet differentiation and function may be useful to improve β-cell differentiation protocols and discover novel therapeutic targets for prevention and treatment of diabetes. Springer Science+Business Media New York, 2013 Epigenetics nationallicence Regulation nationallicence Endocrine cell differentiation nationallicence Beta-cell function nationallicence Methylation nationallicence Histone deacetylase nationallicence MicroRNA nationallicence Diabetes nationallicence Pancreatic islets nationallicence Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 624-632 1534-4827 13:5<624 2013 13 11892 https://doi.org/10.1007/s11892-013-0403-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0403-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Haumaitre Cecile CNRS UMR 7622, Université Pierre et Marie Curie, INSERM U969, 9 quai Saint Bernard, 75005, Paris, France aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 624-632 1534-4827 13:5<624 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer