naa a22 4500 510779859 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0415-7 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0415-7 Antigen-Based Vaccination and Prevention of Type 1 Diabetes [Elektronische Daten] [Leonard Harrison, John Wentworth, Yuxia Zhang, Esther Bandala-Sanchez, Ralph Böhmer, Alana Neale, Natalie Stone, Gaetano Naselli, Julian Bosco, Priscilla Auyeung, Maryam Rashidi, Petra Augstein, Grant Morahan] Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle-dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism. Springer Science+Business Media New York, 2013 Autoimmune nationallicence Type 1 diabetes nationallicence Islet nationallicence β cell nationallicence Preclinical nationallicence Autoantibody nationallicence T cell nationallicence Regulation nationallicence Prediction nationallicence Prevention nationallicence Vaccination nationallicence Insulin nationallicence GAD65 nationallicence Mucosa nationallicence Nasal nationallicence Oral nationallicence Immune nationallicence Suppression nationallicence Tolerance nationallicence Clinical trial nationallicence Antigen nationallicence Harrison Leonard Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Wentworth John Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Zhang Yuxia Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Bandala-Sanchez Esther Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Böhmer Ralph Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Neale Alana Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Stone Natalie Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Naselli Gaetano Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Bosco Julian Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Auyeung Priscilla Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Rashidi Maryam Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Augstein Petra Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Morahan Grant Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 616-623 1534-4827 13:5<616 2013 13 11892 https://doi.org/10.1007/s11892-013-0415-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0415-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harrison Leonard Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Wentworth John Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Zhang Yuxia Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Bandala-Sanchez Esther Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Böhmer Ralph Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Neale Alana Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Stone Natalie Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Naselli Gaetano Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Bosco Julian Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Auyeung Priscilla Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Rashidi Maryam Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Augstein Petra Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Morahan Grant Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 616-623 1534-4827 13:5<616 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer