naa a22 4500 510779867 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0399-3 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0399-3 Immune Monitoring of Islet and Pancreas Transplant Recipients [Elektronische Daten] [J. Abreu, B. Roep] Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta-cells are destroyed. Islet or pancreas transplantation can restore insulin secretion and are established therapies for subgroups of T1D patients. Long-term insulin-independence is, however, hampered by recurrent autoimmunity and rejection. Accurate monitoring of these immune events is therefore of critical relevance for the timely detection of deleterious immune responses. The identification of relevant immune biomarkers of allo- and autoreactivity has allowed a more accurate monitoring of disease progression and responses to therapy at early stages, allowing proper therapeutic intervention, and possibly improvements in the success rate of islet and pancreas transplantation. This review describes the tools established and validated to monitor immune correlates of auto- and alloreactivity that associate with clinical outcome and identifies challenges that current immunosuppression strategies trying to preserve islet graft function face. European Union, 2013 Type 1 diabetes nationallicence Autoimmune disease nationallicence Islet transplantation nationallicence Pancreas transplantation nationallicence Immune monitoring nationallicence Biomarkers nationallicence Abreu J. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, NL-2300Rc, Leiden, The Netherlands aut Roep B. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, NL-2300Rc, Leiden, The Netherlands aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 704-712 1534-4827 13:5<704 2013 13 11892 https://doi.org/10.1007/s11892-013-0399-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0399-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abreu J. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, NL-2300Rc, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Roep B. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, NL-2300Rc, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 704-712 1534-4827 13:5<704 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer