naa a22 4500 510779883 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0402-z doi (NATIONALLICENCE)springer-10.1007/s11892-013-0402-z Use of Glucagon-Like Peptide-1 Agonists to Improve Islet Graft Performance [Elektronische Daten] [Yong Wang, Meirigeng Qi, James McGarrigle, Brian Rady, Maureen Davis, Pilar Vaca, Jose Oberholzer] Human islet transplantation is an effective and promising therapy for type I diabetes. However, long-term insulin independence is both difficult to achieve and inconsistent. De novo or early administration of incretin-based drugs is being explored for improving islet engraftment. In addition to its glucose-dependent insulinotropic effects, incretins also lower postprandial glucose excursion by inhibiting glucagon secretion, delaying gastric emptying, and can protect beta-cell function. Incretin therapy has so far proven clinically safe and tolerable with little hypoglycemic risk. The present review aims to highlight the new frontiers in research involving incretins from both in vitro and in vivo animal studies in the field of islet transplant. It also provides an overview of the current clinical status of incretin usage in islet transplantation in the management of type I diabetes. Springer Science+Business Media New York, 2013 GLP-1 nationallicence GLP-1 receptor nationallicence Exendin-4 nationallicence Liraglutide nationallicence DPP IV inhibitor nationallicence Pancreatic islet of Langerhans and beta-cells nationallicence Human islet transplantation nationallicence Glycemia nationallicence Glucagon-like peptide-1 nationallicence Islet graft performance nationallicence Wang Yong Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Qi Meirigeng Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut McGarrigle James Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Rady Brian Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Davis Maureen Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Vaca Pilar Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Oberholzer Jose Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 723-732 1534-4827 13:5<723 2013 13 11892 https://doi.org/10.1007/s11892-013-0402-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0402-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Yong Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Qi Meirigeng Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- McGarrigle James Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Rady Brian Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Davis Maureen Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Vaca Pilar Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Oberholzer Jose Department of Surgery/Transplant, University of Illinois at Chicago, 60612, Chicago, IL, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 723-732 1534-4827 13:5<723 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer