naa a22 4500 510779956 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0406-8 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0406-8 The Changing Landscape of Type 1 Diabetes: Recent Developments and Future Frontiers [Elektronische Daten] [Kendra Vehik, Nadim Ajami, David Hadley, Joseph Petrosino, Brant Burkhardt] Type 1 diabetes (T1D) research has made great strides over the past decade with advances in understanding the pathogenesis, natural history, candidate environmental exposures, exposure triggering time, disease prediction, and diagnosis. Major monitoring efforts have provided baseline historical measures, leading to better epidemiological studies incorporating longitudinal biosamples (ie, biobanks), which have allowed for new technologies (‘omics') to further expose the etiological agents responsible for the initiation, progression, and eventual clinical onset of T1D. These new frontiers have brought forth high-dimensionality data, which have furthered the evidence of the heterogeneous nature of T1D pathogenesis and allowed for a more mechanistic approach in understanding the etiology of T1D. This review will expand on the most recent advances in the quest for T1D determinants, drawing upon novel research tools that epidemiology, genetics, microbiology, and immunology have provided, linking them to the major hypotheses associated with T1D etiology, and discussing the future frontiers. Springer Science+Business Media New York, 2013 Type 1 diabetes nationallicence Epidemiology nationallicence Gene-environment interaction nationallicence Treg nationallicence Microbiome nationallicence Gut immunity nationallicence Metagenome nationallicence Metabolome nationallicence Vehik Kendra Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut Ajami Nadim Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, 77030, Houston, TX, USA aut Hadley David Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut Petrosino Joseph Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, 77030, Houston, TX, USA aut Burkhardt Brant Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 642-650 1534-4827 13:5<642 2013 13 11892 https://doi.org/10.1007/s11892-013-0406-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0406-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vehik Kendra Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Ajami Nadim Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Hadley David Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Petrosino Joseph Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Burkhardt Brant Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, 3650 Spectrum Blvd, Ste 100, 33612, Tampa, FL, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 642-650 1534-4827 13:5<642 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer