naa a22 4500 510779964 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0400-1 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0400-1 Making β Cells from Adult Cells Within the Pancreas [Elektronische Daten] [Philippe Lysy, Gordon Weir, Susan Bonner-Weir] Cell therapy is currently considered as a potential therapeutic alternative to traditional treatments of diabetes. Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. Current limitations of these procedures have led to the search for strategies targeting replication of pre-existing β cells or transdifferentiation of progenitors and adult cells. These investigations revealed an unexpected plasticity towards β cells of adult cells residing in pancreatic epithelium (eg, acinar, duct, and α cells). Here we discuss recent developments in β-cell replication and β-cell transdifferentiation of adult epithelial pancreatic cells, with an emphasis on techniques with a potential for clinical translation. Springer Science+Business Media New York, 2013 Diabetes nationallicence Pancreas nationallicence Replication nationallicence Progenitors nationallicence Transdifferentiation nationallicence β cells nationallicence Adult cells nationallicence Lysy Philippe Institut de Recherche Expérimentale et Clinique, Pôle de Pédiatrie, Avenue Hippocrate 10, 1200, Brussels, Belgium aut Weir Gordon Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, 1 Joslin Place, 02215, Boston, MA, USA aut Bonner-Weir Susan Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, 1 Joslin Place, 02215, Boston, MA, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 695-703 1534-4827 13:5<695 2013 13 11892 https://doi.org/10.1007/s11892-013-0400-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0400-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lysy Philippe Institut de Recherche Expérimentale et Clinique, Pôle de Pédiatrie, Avenue Hippocrate 10, 1200, Brussels, Belgium aut NATIONALLICENCE 700 1- Weir Gordon Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, 1 Joslin Place, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Bonner-Weir Susan Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, 1 Joslin Place, 02215, Boston, MA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 695-703 1534-4827 13:5<695 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer