naa a22 4500 510779972 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11892-013-0405-9 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0405-9 Novel Diabetes Autoantibodies and Prediction of Type 1 Diabetes [Elektronische Daten] [Janet Wenzlau, John Hutton] Autoantibodies are currently the most robust biomarkers of type 1 diabetes and are frequently used to establish entry criteria for the participation of genetically at-risk individuals in secondary prevention/intervention clinical trials. Since their original description almost 40 years ago, considerable efforts have been devoted toward identifying the precise molecular targets that are recognized. Such information can have significant benefit for developing improved metrics for identifying/stratifying of at-risk subjects, developing potential therapeutic targets, and advancing understanding of the pathophysiology of the disease. Currently, four major molecular targets ([pro]insulin, GAD65, IA-2, and ZnT8) have been confirmed, with approximately 94% of all subjects with a clinical diagnosis of type 1 diabetes expressing autoantibodies to at least one of these molecules at clinical onset. In this review, we summarize some of the salient properties of these targets that might contribute to their autoantigenicity and methods that have been used in attempts to identify new components of the humoral autoresponse. Springer Science+Business Media New York, 2013 Autoantigen nationallicence Autoantibody nationallicence Zinc transporter 8 nationallicence Type 1 diabetes nationallicence Wenzlau Janet Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, 80045, Aurora, CO, USA aut Hutton John Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, 80045, Aurora, CO, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 608-615 1534-4827 13:5<608 2013 13 11892 https://doi.org/10.1007/s11892-013-0405-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0405-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wenzlau Janet Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Hutton John Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/5(2013-10-01), 608-615 1534-4827 13:5<608 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer