naa a22 4500 510780032 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-012-0356-6 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0356-6 The Links Between Insulin Resistance, Diabetes, and Cancer [Elektronische Daten] [Etan Orgel, Steven Mittelman] The growing epidemic of obesity has resulted in a large increase in multiple related diseases. Recent evidence has strengthened the proposed synergistic relationship between obesity-related insulin resistance (IR) and/or diabetes mellitus (DM) and cancer. Within the past year, many studies have examined this relationship. Although the precise mechanisms and pathways are uncertain, it is becoming clear that hyperinsulinemia and possibly sustained hyperglycemia are important regulators of not only the development of cancer but also of treatment outcome. Further, clinical decision-making regarding the treatment of choice for DM will likely be impacted as we learn more about the non-metabolic effects of the available hyperglycemic agents. In our review, we endeavored to synthesize the recent literature and provide a concise view of the journey from macro-level clinical associations to specific mechanistic relationships being elucidated in cell lines and animal models. Springer Science+Business Media New York, 2012 Apoptosis nationallicence Caloric restriction nationallicence Cancer nationallicence Chemotherapy resistance nationallicence Glargine nationallicence Insulin nationallicence Insulin resistance nationallicence Metabolic syndrome nationallicence Metformin nationallicence Obesity nationallicence Proliferation nationallicence Diabetes nationallicence Orgel Etan Jonathan Jaques Children's Cancer Center, Keck School of Medicine, University of Southern California, Miller Children's Hospital, 2801 Atlantic Avenue, 90806, Long Beach, CA, USA aut Mittelman Steven Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, MS #93, 90027, Los Angeles, CA, USA aut Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 213-222 1534-4827 13:2<213 2013 13 11892 https://doi.org/10.1007/s11892-012-0356-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0356-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Orgel Etan Jonathan Jaques Children's Cancer Center, Keck School of Medicine, University of Southern California, Miller Children's Hospital, 2801 Atlantic Avenue, 90806, Long Beach, CA, USA aut NATIONALLICENCE 700 1- Mittelman Steven Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, MS #93, 90027, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 213-222 1534-4827 13:2<213 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer