naa a22 4500 510780040 CHVBK 20180411083243.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-012-0361-9 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0361-9 Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine [Elektronische Daten] [Silvia Sookoian, Carlos Pirola] In this article, we review the current knowledge of and recent insights into the role of epigenetic factors in the development of insulin resistance (IR), with emphasis on peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A or PGC1α) methylation on fetal programming and liver modulation of glucose-related phenotypes. We discuss the pathogenesis of IR beyond the integrity of β-cell function and illustrate the novel concept of mitochondrial epigenetics to explain the pathobiology of metabolic-syndrome-related phenotypes. Moreover, we discuss whether epigenetic marks in genes of the circadian rhythm system are able to modulate insulin/glucose-related metabolic functions and place hypoxia inducible factor 1 α (HIF1α) as a part of the master CLOCK gene/protein interaction network that might modulate IR. Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection. Springer Science+Business Media New York, 2013 Epigenetics nationallicence DNA methylation nationallicence Fatty liver nationallicence NASH nationallicence PPARGC1A nationallicence PGC1a nationallicence Insulin resistance nationallicence Mitochondria nationallicence Histones nationallicence Acetylation nationallicence Deacetylation nationallicence Hypoxia nationallicence Translational medicine nationallicence Sookoian Silvia Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina aut Pirola Carlos Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National-Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina aut Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 229-237 1534-4827 13:2<229 2013 13 11892 https://doi.org/10.1007/s11892-012-0361-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0361-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sookoian Silvia Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Pirola Carlos Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National-Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 229-237 1534-4827 13:2<229 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer