naa a22 4500 510780059 CHVBK 20180411083244.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-013-0364-1 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0364-1 Clues from Bariatric Surgery: Reversing Insulin Resistance to Heal the Heart [Elektronische Daten] [Khaled Khalaf, Heinrich Taegtmeyer] Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs. Springer Science+Business Media New York, 2013 Insulin resistance nationallicence Diabetes nationallicence Obesity nationallicence Bariatric surgery nationallicence Gastric bypass nationallicence Lipotoxicity nationallicence Khalaf Khaled Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, 6431 Fannin, MSB 1.246, 77030, Houston, TX, USA aut Taegtmeyer Heinrich Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, 6431 Fannin, MSB 1.246, 77030, Houston, TX, USA aut Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 245-251 1534-4827 13:2<245 2013 13 11892 https://doi.org/10.1007/s11892-013-0364-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0364-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khalaf Khaled Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, 6431 Fannin, MSB 1.246, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Taegtmeyer Heinrich Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School at Houston, 6431 Fannin, MSB 1.246, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 245-251 1534-4827 13:2<245 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer