naa a22 4500 510780105 CHVBK 20180411083244.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-012-0354-8 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0354-8 Kitazawa Masashi Biological Systems Control Team, Chemical Biology Project, Research and Development Department, Biomedicinal Information Research Center, National of Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, 135-0064, Tokyo, Japan aut Circadian Rhythms, Metabolism, and Insulin Sensitivity: Transcriptional Networks in Animal Models [Elektronische Daten] [Masashi Kitazawa] Homeostatic systems have adapted to respond to the diurnal light/dark cycle. Numerous physiological pathways, including metabolism, are coordinated by this 24-h cycle. Animals with mutations in clock genes show abnormal glucose and lipid metabolism, indicating a critical relationship between the circadian clock and metabolism. Energy homeostasis is achieved through circadian regulation of the expression and activity of several key metabolic enzymes. Temporal organization of tissue metabolism is coordinated by reciprocal cross-talk between the core clock mechanism and key metabolic enzymes and transcriptional activators. The aim of this review is to define the role of the circadian clock in the regulation of insulin sensitivity by describing the interconnection between the circadian clock and metabolic pathways. Springer Science+Business Media New York, 2012 Circadian rhythm nationallicence Metabolism nationallicence Gene transcription and translation nationallicence Insulin sensitivity nationallicence Animal models nationallicence Diabetes nationallicence Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 223-228 1534-4827 13:2<223 2013 13 11892 https://doi.org/10.1007/s11892-012-0354-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0354-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kitazawa Masashi Biological Systems Control Team, Chemical Biology Project, Research and Development Department, Biomedicinal Information Research Center, National of Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, 135-0064, Tokyo, Japan aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 223-228 1534-4827 13:2<223 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer