naa a22 4500 510780113 CHVBK 20180411083244.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-013-0363-2 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0363-2 Interventions to Preserve Beta-Cell Function in the Management and Prevention of Type 2 Diabetes [Elektronische Daten] [Kathleen Page, Tamar Reisman] The International Diabetes Federation estimates that there are currently 336 million people worldwide who have type 2 diabetes (T2DM), and the global prevalence of diabetes has more than doubled since 1980. The rapid rise in rates of T2DM echoes a similar rise in rates of obesity, which causes insulin resistance and places an increased insulin secretory demand on pancreatic β cells. While diabetes is diagnosed clinically by elevated plasma glucose levels, loss of β-cell function is progressive over time and β-cell dysfunction is far advanced by the time diabetes is diagnosed. Methods for preserving or restoring β-cell function are important for the prevention and treatment of T2DM. Interventions that reduce body fat or that change fat biology provide the best evidence for slowing or arresting the deterioration of β-cell function that causes T2DM. These interventions should form the basis of interventions to prevent and treat T2DM, particularly early in its course. Springer Science+Business Media New York, 2013 Diabetes nationallicence Prevention nationallicence β-cell function nationallicence Glucose nationallicence Type 2 diabetes nationallicence Page Kathleen Division of Endocrinology and Diabetes, Department of Internal Medicine, Keck School of Medicine, University of Southern California, 1333 San Pablo Street; BMT-B11, 90033, Los Angeles, CA, USA aut Reisman Tamar Department of Internal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 252-260 1534-4827 13:2<252 2013 13 11892 https://doi.org/10.1007/s11892-013-0363-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0363-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Page Kathleen Division of Endocrinology and Diabetes, Department of Internal Medicine, Keck School of Medicine, University of Southern California, 1333 San Pablo Street; BMT-B11, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Reisman Tamar Department of Internal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 252-260 1534-4827 13:2<252 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer