naa a22 4500 510780156 CHVBK 20180411083244.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11892-012-0358-4 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0358-4 Role of Vitamin D in the Development of Insulin Resistance and Type 2 Diabetes [Elektronische Daten] [Stefan Pilz, Katharina Kienreich, Femke Rutters, Renate de Jongh, Adriana van Ballegooijen, Martin Grübler, Andreas Tomaschitz, Jacqueline Dekker] Vitamin D deficiency is mainly a consequence of insufficient sunlight induced vitamin D production in the skin and has been associated with various chronic diseases including type 2 diabetes. Experimental data have shown that vitamin D is important for glucose induced insulin secretion, improves insulin resistance, and exerts anti-inflammatory actions. Epidemiological studies have largely documented that a poor vitamin D status is associated with higher risk of insulin resistance and type 2 diabetes. The majority of randomized controlled trials (RCTs) in healthy or prediabetic individuals have, however, failed to demonstrate relevant vitamin D effects on insulin resistance or diabetes incidence. In patients with type 2 diabetes, a few RCTs reported some moderate effects of vitamin D on glycemic control and insulin resistance. While these findings warrant further in-depth studies, the current evidence is insufficient to recommend vitamin D supplementation for the prevention or treatment of type 2 diabetes. Springer Science+Business Media New York, 2012 Vitamin D nationallicence Cholecalciferol nationallicence Insulin resistance nationallicence Diabetes nationallicence Glucose metabolism nationallicence Pilz Stefan Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut Kienreich Katharina Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria aut Rutters Femke Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut de Jongh Renate Department of Internal Medicine and Endocrinology and Metabolism, VU University Medical Centre, Amsterdam, The Netherlands aut van Ballegooijen Adriana Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands aut Grübler Martin Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria aut Tomaschitz Andreas Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria aut Dekker Jacqueline Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut Current Diabetes Reports Current Science Inc. 13/2(2013-04-01), 261-270 1534-4827 13:2<261 2013 13 11892 https://doi.org/10.1007/s11892-012-0358-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0358-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pilz Stefan Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Kienreich Katharina Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Rutters Femke Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Jongh Renate Department of Internal Medicine and Endocrinology and Metabolism, VU University Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Ballegooijen Adriana Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Grübler Martin Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Tomaschitz Andreas Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Dekker Jacqueline Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/2(2013-04-01), 261-270 1534-4827 13:2<261 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer