naa a22 4500 510784348 CHVBK 20180411083257.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12045-013-0071-x doi (NATIONALLICENCE)springer-10.1007/s12045-013-0071-x A serpentine way to signaling [Elektronische Daten] Nobel Prize in Chemistry, 2012 [Vignesh Hariharan, Raji Nair, Deepak Saini] The Nobel Prize in Chemistry, 2012 has been awarded to Robert J Lefkowitz and Brian K Kobilka for their studies on G-Protein Coupled Receptors (GPCRs). GPCRs are receptor proteins present on the cell surface, which are involved in sensing molecules outside the cell and initiating a cellular response. They can sense a wide variety of ligands ranging from light to hormones and small peptides, triggering various physiological responses. Today we understand the molecular mechanisms by which these receptors work largely due to the contributions of Lefkowitz and Kobilka. Owing to the role of GPCRs in cell communication and involvement in various disease conditions, they are targets of over 40% of current drugs in the market. These findings have not only revealed how GPCRs work, but have also made a huge impact on the field of GPCR-associated drug discovery. Indian Academy of Sciences, 2013 Receptor nationallicence GPCR nationallicence crystal structure nationallicence drug discovery nationallicence Hariharan Vignesh Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut Nair Raji Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut Saini Deepak Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut Resonance Springer-Verlag 18/6(2013-06-01), 530-542 0971-8044 18:6<530 2013 18 12045 https://doi.org/10.1007/s12045-013-0071-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12045-013-0071-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hariharan Vignesh Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut NATIONALLICENCE 700 1- Nair Raji Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut NATIONALLICENCE 700 1- Saini Deepak Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, 560 012, Bangalore, India aut NATIONALLICENCE 773 0- Resonance Springer-Verlag 18/6(2013-06-01), 530-542 0971-8044 18:6<530 2013 18 12045 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer