naa a22 4500 510785646 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12603-012-0091-3 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0091-3 Cerebrovascular disease and gait and balance impairment in mild to moderate Alzheimer's disease [Elektronische Daten] [Marco Inzitari, M. Gine-Garriga, B. Martinez, M. Perez-Fernandez, E. Barranco-Rubia, A. Lleo, A. Salva-Casanovas] Objectives: Gait and movement abnormalities are traditionally considered infrequent in patients with mild/moderate Alzheimer's disease (AD). However, an increased risk of falls and gait abnormalities has been detected, even in early stages of the disease. Whether these abnormalities are associated with cerebrovascular disease, which has a high prevalence in AD, remains unclear. Design: Cross-sectional study. Setting: Dementia outpatient clinics. Participants: 24 mild/moderate AD patients with (AD+CVD) and 20 without (AD-CVD) cerebrovascular disease without a history of stroke and antipsychotic medications. Measurements: Physical performance, measured with the Short Physical Performance Battery [SPPB], a summary measure combining 4-meter gait speed, balance and muscle strength, and with 8-meter gait speed with a turn was compared between the two groups. Results: AD+CVD patients showed a significant higher prevalence of 4-meter gait speed slower than 0,8 m/s (37.5% Vs 5%, p-value=0.01) and balance impairment (37.5% Vs 10%, p-value=0.038), as well as a slower 8-meter gait speed with a turn (mean+SD=0.6±0.2 Vs 0.8±0.2, p-value=0.024). These associations were confirmed in multivariable models. No differences were observed for muscle strength. Conclusion: In our sample, AD with cerebrovascular disease had worse gait and balance than AD without cerebrovascular disease. If confirmed, these results may have clinical implications, since cerebrovascular disease can be potentially prevented. Serdi and Springer Verlag France, 2013 Alzheimer's disease nationallicence physical function gait nationallicence falls nationallicence cerebrovascular nationallicence Inzitari Marco Institute on Aging of the Universitat Autònoma de Barcelona, Barcelona, Spain aut Gine-Garriga M. Association of Physical Therapists of Catalonia, Barcelona, Spain aut Martinez B. Association of Physical Therapists of Catalonia, Barcelona, Spain aut Perez-Fernandez M. Pere Virgili Hospital, Bercelona, Spain aut Barranco-Rubia E. Granollers Hospital, Granollers, Spain aut Lleo A. Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain aut Salva-Casanovas A. Institute on Aging of the Universitat Autònoma de Barcelona, Barcelona, Spain aut The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 45-48 1279-7707 17:1<45 2013 17 12603 https://doi.org/10.1007/s12603-012-0091-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0091-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inzitari Marco Institute on Aging of the Universitat Autònoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Gine-Garriga M. Association of Physical Therapists of Catalonia, Barcelona, Spain aut NATIONALLICENCE 700 1- Martinez B. Association of Physical Therapists of Catalonia, Barcelona, Spain aut NATIONALLICENCE 700 1- Perez-Fernandez M. Pere Virgili Hospital, Bercelona, Spain aut NATIONALLICENCE 700 1- Barranco-Rubia E. Granollers Hospital, Granollers, Spain aut NATIONALLICENCE 700 1- Lleo A. Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain aut NATIONALLICENCE 700 1- Salva-Casanovas A. Institute on Aging of the Universitat Autònoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 45-48 1279-7707 17:1<45 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer