naa a22 4500 510785670 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12603-012-0381-9 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0381-9 The advanced activities of daily living: A tool allowing the evaluation of subtle functional decline in mild cognitive impairment [Elektronische Daten] [P. De Vriendt, E. Gorus, E. Cornelis, I. Bautmans, M. Petrovic, T. Mets] Objectives: Assessment of advanced activities of daily living (a-ADL) can be of interest in establishing the diagnosis of Alzheimer's disease (AD) in an earlier stage, since these activities demand high cognitive functioning and are more responsive to subtle changes. In this study we tested a new a-ADL tool, developed according to the International Classification of Functioning, Disability and Health (ICF). The a-ADL tool is based on the total number of activities performed (TNA) by a person and takes each subject as his own reference. It distinguishes a total Disability Index (a-ADL-DI), a Cognitive Disability Index (a-ADL-CDI), and a Physical Disability Index (a-ADL-PDI), with lower score representing more independency. We explored whether these indices allow distinction between cognitively healthy persons, patients with Mild Cognitive Impairment (MCI) and patients with mild AD. Methods: Participants were on average 80 years old (SD 4.6; 66-90), were community dwelling, and were diagnosed as (1) cognitively healthy subjects (n=26); (2) patients with MCI (n = 17), or (3) mild AD (n = 25), based upon extensive clinical evaluation and a set of global, cognitive, mood and functional assessments. The a-ADL-tool was not part of the clinical evaluation. Results: The a-ADL-CDI was significantly different between the three groups (p<.01). The a-ADL-DI was significantly different between MCI and AD (p<.001). The tool had good psychometrical properties (inter-rater reliability; agreement between patient and proxy; correlations with cognitive tests). Although the sample size was relatively small, ROC curves were computed for the a-ADL-DI and a-ADL-CDI with satisfactory and promising results. Conclusion: The a-ADLCDI and a-ADL-DI might offer a useful contribution to the identification and follow up of patients with mild cognitive disorders in an older population. Serdi and Springer-Verlag France, 2013 International classification of functioning nationallicence disability and health nationallicence cognitive disorders nationallicence Alzheimer's disease nationallicence assessment of daily functioning nationallicence geriatric assessment nationallicence De Vriendt P. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Gorus E. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Cornelis E. Department of Geriatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut Bautmans I. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut Petrovic M. Department of Geriatrics, Ghent University Hospital, De Pintelaan, 185, 9000, Ghent, Belgium aut Mets T. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 64-71 1279-7707 17:1<64 2013 17 12603 https://doi.org/10.1007/s12603-012-0381-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0381-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Vriendt P. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Gorus E. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Cornelis E. Department of Geriatrics, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Bautmans I. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Petrovic M. Department of Geriatrics, Ghent University Hospital, De Pintelaan, 185, 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Mets T. Frailty in Ageing (FRIA) research group and Gerontology department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 64-71 1279-7707 17:1<64 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer