naa a22 4500 510785697 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12603-012-0415-3 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0415-3 The impact of supplemental N-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women [Elektronische Daten] [H. Hutchins-Wiese, A. Kleppinger, K. Annis, E. Liva, C. Lammi-Keefe, H. Durham, A. Kenny] Objectives: Identify relationships and evaluate effects of long chain polyunsaturated fatty acids (LCPUFA) on frailty and physical performance. Design: Randomized, double blind pilot study. Setting: University General Clinical Research Center. Participants: 126 postmenopausal women. Intervention: 2 fish oil (1.2g eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) or 2 placebo (olive oil) capsules per day for 6 months. All participants received calcium and vitamin D supplements. Measurements: Fatty acid levels, frailty assessment, hand grip strength, 8 foot walk, body composition, medical history and co-morbidities, nutrient intake, and inflammatory biomarkers taken at baseline and 6 months. Results: At baseline, those with greater red blood cell (RBC) DHA and DHA/arachidonic acid (AA) presented with less frailty (r=−0.242, p=0.007 and r=−0.254, p=0.004, respectively). Fish oil supplementation resulted in higher RBC DHA and lower AA compared to baseline and placebo (p<0.001) and an improvement in walking speed compared to placebo (3.0±16 vs. −3.5±14, p=0.038). A linear regression model included age, antioxidant intake (selenium and vitamin C), osteoarthritis, frailty phenotype, and tumor necrosis factor alpha (TNFα). The model explained 13.6% of the variance in the change in walking speed. Change in DHA/AA (p=0.01) and TNFα (p=0.039), and selenium intake (p=0.031) had the greatest contribution to change in walking speed. Conclusion: Physical performance, measured by change in walking speed, was significantly affected by fish oil supplementation. Dietary intake of antioxidants (selenium and vitamin C) and changes in TNFα also contributed to change in walking speed suggesting LCPUFA may interact with antioxidants and inflammatory response to impact physical performance. Serdi and Springer-Verlag France, 2013 Long chain polyunsaturated fatty acids nationallicence antioxidants nationallicence physical performance nationallicence frailty nationallicence Hutchins-Wiese H. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut Kleppinger A. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut Annis K. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut Liva E. Vital Nutrients, Middletown, CT, USA aut Lammi-Keefe C. Human Nutrition & Food, School of Human Ecology and Agricultural Center, Louisiana State University, Baton Rouge, LA, USA aut Durham H. Human Nutrition & Food, School of Human Ecology and Agricultural Center, Louisiana State University, Baton Rouge, LA, USA aut Kenny A. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 76-80 1279-7707 17:1<76 2013 17 12603 https://doi.org/10.1007/s12603-012-0415-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0415-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hutchins-Wiese H. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut NATIONALLICENCE 700 1- Kleppinger A. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut NATIONALLICENCE 700 1- Annis K. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut NATIONALLICENCE 700 1- Liva E. Vital Nutrients, Middletown, CT, USA aut NATIONALLICENCE 700 1- Lammi-Keefe C. Human Nutrition & Food, School of Human Ecology and Agricultural Center, Louisiana State University, Baton Rouge, LA, USA aut NATIONALLICENCE 700 1- Durham H. Human Nutrition & Food, School of Human Ecology and Agricultural Center, Louisiana State University, Baton Rouge, LA, USA aut NATIONALLICENCE 700 1- Kenny A. Center on Aging, University of Connecticut Health Center, Farmington, CT, USA aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 76-80 1279-7707 17:1<76 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer