naa a22 4500 510785794 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12603-012-0424-2 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0424-2 Atherosclerosis and physical functioning in older men, a longitudinal study [Elektronische Daten] [M. Den Ouden, M. Schuurmans, E. Arts, D. Grobbee, M. Bots, A. Van Den Beld, S. Lamberts, Y. Van Der Schouw] Objective: Functional decline is a major threat to independency, progressing into functional limitations and eventually leading to disability. Chronic diseases, especially cardiovascular diseases, are important determinants of functional limitations and disability. Vascular damage exits long before it is clinically manifest and can have adverse effects on health, physical and cognitive functioning. The objective was to investigate the association between non-invasive atherosclerosis measures and physical functioning in older men. Design: Prospective cohort study. Setting: The study was conducted in the general community. Participants: 195 independently living older men. Measurements: Atherosclerosis was measured by intima media thickness (CIMT) of the common carotid artery using ultrasonography and assessment for presence of atherosclerotic plaques. Physical functioning was measured by isometric handgrip strength and leg extensor strength using a hand held dynamometer, lower extremity function using the physical performance score and ability to perform activities of daily life using the modified Stanford Health Assessment Questionnaire. Linear regression analysis was performed to estimate the associations between CIMT or plaques and physical functioning. Results: After adjustment for confounders, higher baseline CIMT was associated with lower isometric handgrip strength at follow up (βCIMT =−7.21, 95% CI[−13.64;−0.77]). No other associations were found between CIMT and physical functioning. In addition, no associations were found for the presence of plaques and physical functioning either at baseline, or at follow-up. Conclusion: Atherosclerosis, as measured by higher CIMT, is related to a lower isometric handgrip strength at follow-up, but no further associations with physical functioning were found in this longitudinal study among independently living older men. Serdi and Springer-Verlag France, 2013 Non-invasive atherosclerosis measures nationallicence carotid intima media thickness nationallicence physical function nationallicence grip strength nationallicence elderly nationallicence Den Ouden M. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut Schuurmans M. Faculty Chair Care for the Chronically Ill and Elderly, University of applied sciences Utrecht, Utrecht, The Netherlands aut Arts E. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut Grobbee D. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut Bots M. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut Van Den Beld A. Department of Internal Medicine, Groene Hart Ziekenhuis, Gouda, The Netherlands aut Lamberts S. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands aut Van Der Schouw Y. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 97-104 1279-7707 17:1<97 2013 17 12603 https://doi.org/10.1007/s12603-012-0424-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0424-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Den Ouden M. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Schuurmans M. Faculty Chair Care for the Chronically Ill and Elderly, University of applied sciences Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Arts E. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Grobbee D. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Bots M. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Van Den Beld A. Department of Internal Medicine, Groene Hart Ziekenhuis, Gouda, The Netherlands aut NATIONALLICENCE 700 1- Lamberts S. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Van Der Schouw Y. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/1(2013-01-01), 97-104 1279-7707 17:1<97 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer