naa a22 4500 510785824 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12603-013-0027-6 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0027-6 Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial [Elektronische Daten] [Elena Martinez-Lapiscina, P. Clavero, E. Toledo, B. San Julian, A. Sanchez-Tainta, D. Corella, R. Lamuela-Raventos, J. Martinez, M. Martinez-Gonzalez] Objective: XXXto assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet). Design: XXXrandomized trial after 6.5 years of nutritional intervention. Setting: Eight primary care centers affiliated to the University of Navarra. Participants: A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1± 5.7 years at cognitive evaluation). Interventions: Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter. Measurements: XXXcognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention. Results: Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls. Conclusion: A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls. Serdi and Springer-Verlag France, 2013 Mediterranean diet nationallicence olive oil nationallicence randomized controlled trial nationallicence cognition nationallicence mild cognitive impairment nationallicence Martinez-Lapiscina Elena Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut Clavero P. Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Spain aut Toledo E. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut San Julian B. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut Sanchez-Tainta A. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut Corella D. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut Lamuela-Raventos R. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut Martinez J. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut Martinez-Gonzalez M. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 544-552 1279-7707 17:6<544 2013 17 12603 https://doi.org/10.1007/s12603-013-0027-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0027-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martinez-Lapiscina Elena Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Clavero P. Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Toledo E. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- San Julian B. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Sanchez-Tainta A. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Corella D. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut NATIONALLICENCE 700 1- Lamuela-Raventos R. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut NATIONALLICENCE 700 1- Martinez J. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain aut NATIONALLICENCE 700 1- Martinez-Gonzalez M. Department of Preventive Medicine and Public Health, Medical School-Clinica, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 544-552 1279-7707 17:6<544 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer