naa a22 4500 510785832 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12603-013-0017-8 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0017-8 Celiac disease is not increased in women with hip fractures and low vitamin D levels [Elektronische Daten] [Meryl Leboff, H. Cobb, L. Gao, W. Hawkes, J. Yu-Yahiro, N. Kolatkar, J. Magaziner] Objective: Celiac disease is associated with decreased bone density; however, the risk of fractures in celiac disease patients is unclear. We compared the prevalence of celiac disease between a group of women with hip fractures and a group of women undergoing elective joint replacement surgery and the association between celiac disease and vitamin D levels. Methods: Two hundred eight community dwelling and postmenopausal women were recruited from Boston, MA (n=81) and Baltimore, MD (n=127). We measured tissue transglutaminase IgA by ELISA to diagnose celiac disease and 25-hydroxyvitamin D (25(OH)D) levels by radioimmunoassay in both women with hip fractures (n=157) and a control group (n=51) of total hip replacement subjects from Boston. Subjects were excluded if they took any medications or had medical conditions that might affect bone. Results: Median serum 25(OH)D levels were significantly lower (p< 0.0001) in the hip fracture cohorts compared to the elective joint replacement cohort (14.1 ng/ml vs. 21.3 ng/ml, respectively). There were no differences in the percentage of subjects with a positive tissue transglutaminase in the women with hip fractures versus the control group (1.91% vs. 1.96%, respectively). Conclusion: Vitamin D levels are markedly reduced in women with hip fractures, however hip fracture patients did not show a higher percentage of positive tissue transglutaminase levels compared with controls. These data suggest that routine testing for celiac disease among hip fracture patients may not be necessary in the absence of clinical signs and symptoms, although data from larger studies among hip fracture subjects are needed. Serdi and Springer-Verlag France, 2013 Celiac disease nationallicence hip fracture nationallicence vitamin D nationallicence Leboff Meryl Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut Cobb H. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut Gao L. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut Hawkes W. Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland Baltimore, Suite 200, 660 W. Redwood Street, 21201, Baltimore, MD, USA aut Yu-Yahiro J. Department of Orthopedic Research, The Union Memorial Hospital, Baltimore, MD, USA aut Kolatkar N. F. Hoffmann-La Roche Ltd., Global Medical Affairs, Cardiovascular-Metabolism, Grenzacherstrasse 124, CH-4070, Basel, Switzerland aut Magaziner J. Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland Baltimore, Suite 200, 660 W. Redwood Street, 21201, Baltimore, MD, USA aut The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 562-565 1279-7707 17:6<562 2013 17 12603 https://doi.org/10.1007/s12603-013-0017-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0017-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leboff Meryl Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Cobb H. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Gao L. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Hawkes W. Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland Baltimore, Suite 200, 660 W. Redwood Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Yu-Yahiro J. Department of Orthopedic Research, The Union Memorial Hospital, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Kolatkar N. F. Hoffmann-La Roche Ltd., Global Medical Affairs, Cardiovascular-Metabolism, Grenzacherstrasse 124, CH-4070, Basel, Switzerland aut NATIONALLICENCE 700 1- Magaziner J. Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland Baltimore, Suite 200, 660 W. Redwood Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 562-565 1279-7707 17:6<562 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer