naa a22 4500 510785840 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12603-013-0029-4 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0029-4 A jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging [Elektronische Daten] [M. Garrido, D. Gonzalez-Gomez, M. Lozano, C. Barriga, S. Paredes, Ana Moratinos] Objective: In the present work, we evaluated the effect of the intake of a Jerte Valley cherry-based product (JVCP), compared to a placebo product, on sleep quality, urinary 6-sulfatoxymelatonin (aMT6-s) levels and the serum concentration of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) and interleukin-8 (IL-8). Design: This was a blind, placebo-controlled, randomized, crossover study. Setting: University of Extremadura (Spain). Participants: Ten young (20-30 years old), ten middle-aged (35-55 years old), and ten elderly (65-85 years old) participants. Intervention: A placebo (Kool-Aid®) or JVCP (patent no. ES 2342141 B1) were consumed twice a day, as lunch and dinner desserts. Measurements: Actigraphic monitoring was used to record and display the temporal patterns of the individuals' activity and rest. Urinary aMT6-s and serum cytokines (IL-1β, TNF-α and IL-8) were also determined. Results: The consumption of the JVCP improved the nocturnal rest, measured by sleep efficiency, number of awakenings, total nocturnal activity, sleep latency, assumed sleep, actual sleep time and immobility. Moreover, it was detected an increase in both the levels of aMT6-s found in first-void morning urine and the concentrations of serum pro-somnogenic cytokines obtained from samples collected at the acrophase of the melatonin rhythm (1.00 am) in all experimental age groups after the JVCP consumption. Generally, better results were obtained with advancing age. Conclusion: The ingestion of the JVCP may contribute to establish a high-quality sleep and be used as a potential nutraceutical tool to prevent sleep disorders with the advance of age. Serdi and Springer-Verlag France, 2013 6-sulfatoxymelatonin nationallicence melatonin nationallicence cytokine nationallicence sleep nationallicence sweet cherry nationallicence Garrido M. Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut Gonzalez-Gomez D. Department of Analytical Science, Faculty of Science, Open University, 28040, Madrid, Spain aut Lozano M. Department of Horticulture and Pomology, Technological Institute of Food and Agriculture of Extremadura (INTAEX), 06071, Badajoz, Spain aut Barriga C. Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut Paredes S. Department of Physiology, School of Medicine, Complutense University of Madrid, 28040, Madrid, Spain aut Moratinos Ana Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 553-560 1279-7707 17:6<553 2013 17 12603 https://doi.org/10.1007/s12603-013-0029-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0029-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garrido M. Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut NATIONALLICENCE 700 1- Gonzalez-Gomez D. Department of Analytical Science, Faculty of Science, Open University, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Lozano M. Department of Horticulture and Pomology, Technological Institute of Food and Agriculture of Extremadura (INTAEX), 06071, Badajoz, Spain aut NATIONALLICENCE 700 1- Barriga C. Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut NATIONALLICENCE 700 1- Paredes S. Department of Physiology, School of Medicine, Complutense University of Madrid, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Moratinos Ana Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, 06006, Badajoz, Spain aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 553-560 1279-7707 17:6<553 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer