naa a22 4500 510785859 CHVBK 20180411083301.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12603-013-0047-2 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0047-2 Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons [Elektronische Daten] [K. Swart, N. Van Schoor, M. Heymans, L. Schaap, M. Den Heijer, P. Lips] Objective: The current study aimed to examine homocysteine in relation to different aspects of physical functioning. Design, setting and participants: Cross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged ≥ 65 years (N= 1301 after imputation). Measurements: Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers. Results: Results were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= −3.07 (−4.91; −1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16-2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling. Conclusions: These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men. Serdi and Springer-Verlag France, 2013 Homocysteine nationallicence physical functioning nationallicence muscle nationallicence aging nationallicence Swart K. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut Van Schoor N. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut Heymans M. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut Schaap L. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut Den Heijer M. Department of Internal Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut Lips P. Department of Internal Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 578-584 1279-7707 17:6<578 2013 17 12603 https://doi.org/10.1007/s12603-013-0047-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0047-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swart K. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Van Schoor N. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Heymans M. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Schaap L. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Den Heijer M. Department of Internal Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 700 1- Lips P. Department of Internal Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 578-584 1279-7707 17:6<578 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer