naa a22 4500 510785883 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12603-013-0010-2 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0010-2 Late-life metabolic syndrome prevents cognitive decline among older men aged 75 years and over: One-year prospective cohort study [Elektronische Daten] [C. Liu, M. Lin, L. Peng, Liang-Kung Chen, C. Su, L. Liu, L. Chen] Background: Although metabolic syndrome (MetS) has been reported to be associated with cognitive decline and dementia, little was known about late-life MetS and cognitive decline among older old population. The main purpose of this study was to evaluate the role of MetS and cognitive decline among men aged 75 and over in Taiwan. Methods: This is a prospective cohort study which recruited men aged 75 years and older with intact cognitive function living in the Banciao Veterans Home, a retirement community for veterans in northern Taiwan. All participants received complete history taking, physical examinations, global cognitive tests and laboratory tests. Cognitive status was re-evaluated one year after enrollment to evaluate the role of MetS to cognitive decline in this study population. Results: Overall, 338 people participated in the study and 62 of them were excluded due to low baseline MMSE score, and the remaining 276 people (mean age: 82.4±4.2 years) were enrolled for study. The prevalence of MetS and annual cognitive decline were 22.5% and 15.6%, respectively. During the follow-up period, 9 (3.3%) participants died, 229(83.0%) complete the study. Subjects with cognitive decline were older and had lower serum levels of serum total cholesterol. Multivariate logistic regression showed that older age (OR:1.13, 95% C.I.: 1.01-1.25, P=0.026) and central obesity (OR: 4.19, 95% CI: 1.26-13.91, P=0.019) were independent risk factors for cognitive decline; and MetS defined by Adult Treatment Panel III was a protective factor (OR: 0.20, 95% CI: 0.04-0.94, P=0.041). The protective effect of MetS remained the same when MetS was defined by the criteria of International Diabetes Federation. Conclusions: Age and central obesity were significant risk factors of cognitive decline, but late-life MetS, however defined, had protective effect on cognitive function. Further investigation is needed to clarify the possible mechanism of MetS and cognitive function in older adults. Serdi and Springer-Verlag France, 2013 Cognitive decline nationallicence elderly nationallicence metabolic syndrome nationallicence protective effect nationallicence late life risk nationallicence Liu C. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut Lin M. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut Peng L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut Chen Liang-Kung Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut Su C. Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan aut Liu L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut Chen L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 523-526 1279-7707 17:6<523 2013 17 12603 https://doi.org/10.1007/s12603-013-0010-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0010-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu C. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin M. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Peng L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Liang-Kung Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Su C. Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Liu L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen L. Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/6(2013-06-01), 523-526 1279-7707 17:6<523 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer