naa a22 4500 510786014 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12603-013-0367-2 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0367-2 Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group [Elektronische Daten] [Eirini Kelaiditi, M. Cesari, M. Canevelli, G. Abellan van Kan, P. Ousset, S. Gillette-Guyonnet, P. Ritz, F. Duveau, M. Soto, V. Provencher, F. Nourhashemi, A. Salva, P. Robert, S. Andrieu, Y. Rolland, J. Touchon, J. Fitten, B. Vellas] The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons. In parallel, dementia and cognitive disorders also represent major healthcare and social priorities. Although physical frailty and cognitive impairment have shown to be related in epidemiological studies, their pathophysiological mechanisms have been usually studied separately. An International Consensus Group on "Cognitive Frailty” was organized by the International Academy on Nutrition and Aging (I.A.N.A) and the International Association of Gerontology and Geriatrics (I.A.G.G) on April 16th, 2013 in Toulouse (France). The present report describes the results of the Consensus Group and provides the first definition of a "Cognitive Frailty” condition in older adults. Specific aim of this approach was to facilitate the design of future personalized preventive interventions in older persons. Finally, the Group discussed the use of multidomain interventions focused on the physical, nutritional, cognitive and psychological domains for improving the well-being and quality of life in the elderly. The consensus panel proposed the identification of the so-called "cognitive frailty” as an heterogeneous clinical manifestation characterized by the simultaneous presence of both physical frailty and cognitive impairment. In particular, the key factors defining such a condition include: 1) presence of physical frailty and cognitive impairment (CDR=0.5); and 2) exclusion of concurrent AD dementia or other dementias. Under different circumstances, cognitive frailty may represent a precursor of neurodegenerative processes. A potential for reversibility may also characterize this entity. A psychological component of the condition is evident and concurs at increasing the vulnerability of the individual to stressors. Serdi and Springer-Verlag France, 2013 Frailty nationallicence cognition nationallicence cognitive frailty nationallicence neurodegenerative disease nationallicence aging nationallicence elderly nationallicence disability nationallicence clinical markers nationallicence biological markers nationallicence neuroimaging nationallicence prevention nationallicence Kelaiditi Eirini Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Cesari M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Canevelli M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Abellan van Kan G. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Ousset P. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Gillette-Guyonnet S. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Ritz P. INSERM UMR 1027, Toulouse, France aut Duveau F. Médéos consulting, Garches, France aut Soto M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Provencher V. Département de réadaptation, Université de Laval, Québec, Canada aut Nourhashemi F. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Salva A. Institut Català de l'Envelliment, Universitat Autònoma de Barcelona, Barcelona, Spain aut Robert P. Centre Mémoire de Ressources et de Recherche, CHU Nice, INSERM JE 2441 Neurobiologie et Psychopathologie, Nice, France aut Andrieu S. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Rolland Y. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut Touchon J. Neurology Department, University Hospital of Montpellier, Montpellier, France aut Fitten J. David Geffen School of Medicine, UCLA, Los Angeles, USA aut Vellas B. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut The journal of nutrition, health & aging Springer Paris 17/9(2013-11-01), 726-734 1279-7707 17:9<726 2013 17 12603 https://doi.org/10.1007/s12603-013-0367-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0367-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kelaiditi Eirini Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Cesari M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Canevelli M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Abellan van Kan G. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Ousset P. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Gillette-Guyonnet S. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Ritz P. INSERM UMR 1027, Toulouse, France aut NATIONALLICENCE 700 1- Duveau F. Médéos consulting, Garches, France aut NATIONALLICENCE 700 1- Soto M. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Provencher V. Département de réadaptation, Université de Laval, Québec, Canada aut NATIONALLICENCE 700 1- Nourhashemi F. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Salva A. Institut Català de l'Envelliment, Universitat Autònoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Robert P. Centre Mémoire de Ressources et de Recherche, CHU Nice, INSERM JE 2441 Neurobiologie et Psychopathologie, Nice, France aut NATIONALLICENCE 700 1- Andrieu S. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Rolland Y. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Touchon J. Neurology Department, University Hospital of Montpellier, Montpellier, France aut NATIONALLICENCE 700 1- Fitten J. David Geffen School of Medicine, UCLA, Los Angeles, USA aut NATIONALLICENCE 700 1- Vellas B. Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/9(2013-11-01), 726-734 1279-7707 17:9<726 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer