naa a22 4500 510786022 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12603-013-0349-4 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0349-4 Relationship between anticholinergic drug use and one-year outcome among elderly people hospitalised in medical wards via emergency department: The safes cohort study [Elektronische Daten] [D. Narbey, D. Jolly, R. Mahmoudi, T. Trenque, F. Blanchard, J. Novella, Moustapha Dramé] Aim: To investigate the relationship between anticholinergic drug use and one-year outcome of elderly patients hospitalised via the emergency department. Methods: Prospective, multicentre, cohort study of patients aged 75 years and older. Comprehensive geriatric evaluation was performed. We included in this analysis all patients for whom data on drug use was available. Anticholinergic drugs were coded using the online database "Thesorimed”. One-year mortality and nursing home admission were analysed using a Cox model, with matching on the propensity to use anticholinergic drugs. Results: In total, 1176 subjects were included in this analysis, average age 85±6 years, 65% women. Overall, 144 (12%) were taking at least one anticholinergic drug. Mortality and nursing home admission at one year were respectively 29% and 30% in the anticholinergic group, and 34% and 33% respectively in subjects not taking anticholinergic drugs. No significant relationship was observed between anticholinergic drug use and the main endpoints. Conclusion: Although we did not observed any statistically significant relationship between use of anticholinergic drugs and one-year outcome in elderly patients, the long-term use of anticholinergic drugs can have deleterious effects on memory and functional capacity, and therefore requires prescriptions to be reviewed regularly. Serdi and Springer-Verlag France, 2013 Anticholinergics nationallicence elderly nationallicence mortality nationallicence nursing home placement nationallicence propensity score nationallicence Narbey D. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Jolly D. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Mahmoudi R. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Trenque T. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Blanchard F. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Novella J. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut Dramé Moustapha Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut The journal of nutrition, health & aging Springer Paris 17/9(2013-11-01), 766-771 1279-7707 17:9<766 2013 17 12603 https://doi.org/10.1007/s12603-013-0349-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0349-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Narbey D. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Jolly D. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Mahmoudi R. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Trenque T. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Blanchard F. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Novella J. Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 700 1- Dramé Moustapha Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, Reims, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/9(2013-11-01), 766-771 1279-7707 17:9<766 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer