naa a22 4500 510786057 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12603-013-0350-y doi (NATIONALLICENCE)springer-10.1007/s12603-013-0350-y How to design nutritional intervention trials to slow cognitive decline in apparently healthy populations and apply for efficacy claims: A statement from the international academy on nutrition and aging task force [Elektronische Daten] [M. Ferry, N. Coley, S. Andrieu, C. Bonhomme, J. Caubere, M. Cesari, J. Gautry, I. Garcia Sanchez, L. Hugonot, L. Mansuy, M. Pahor, J. Pariente, P. Ritz, A. Salva, J. Sijben, R. Wieggers, P. Ythier-Moury, M. Zaim, J. Zetlaoui, B. Vellas] interventions are crucial as they offer simple and inexpensive public health solutions that will be useful over the long term use. A Task Force on designing trials of nutritional interventions to slow cognitive decline in older adults was held in Toulouse in September 2012. The aim of the Task Force was to bring together leading experts from academia, the food industry and regulatory agencies to determine the best trial designs that would enable us to reach our goal of maintaining or improving cognitive function in apparently healthy aging people. An associated challenge for this Task Force was to determine the type of trials required by the Public Food Agencies for assessing the impact of nutritional compounds in comparison to well established requirements for drug trials. Although the required quality of the study design, rationale and statistical analysis remains the same, the studies designed to show reduction of cognitive decline require a long duration and the objectives of this task force was to determine best design for these trials. Two specific needs were identified to support trials of nutritional interventions: 1- Risk-reduction strategies are needed to tackle the growing burden of cognitive decline that may lead to dementia, 2- Innovative study designs are needed to improve the quality of these studies. Serdi and Springer-Verlag France, 2013 Cognitive decline nationallicence aging nationallicence design nutritional intervention trials nationallicence efficacy claims nationallicence Ferry M. Nutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13, Paris, France aut Coley N. INSERM U1027, Toulouse, France aut Andrieu S. INSERM U1027, Toulouse, France aut Bonhomme C. Lactalis Nutrition Santé, 35370, Torcé, France aut Caubere J. Pierre Fabre, 81106, Castres, France aut Cesari M. INSERM U1027, Toulouse, France aut Gautry J. Nestlé Clinical Nutrition, 77446, Marne la Vallée, France aut Garcia Sanchez I. DG Sanco, Brussels, Belgium aut Hugonot L. MedForma, Paris, France aut Mansuy L. Pierre Fabre, 81106, Castres, France aut Pahor M. University of Floride, Gainesville, FL, USA aut Pariente J. Department of Neurology, Purpan Hospital, 31000, Toulouse, France aut Ritz P. Nutrition Unit, Toulouse University Hospital, Toulouse, France aut Salva A. Institut Català de l'Envelliment, Universita Autonoma de Barcelona, Barcelona, Spain aut Sijben J. Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition, 6700 CA, Wageningen, The Netherlands aut Wieggers R. Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition, 6700 CA, Wageningen, The Netherlands aut Ythier-Moury P. Sanofi R&D — TSU Aging, 34184, Montpellier, France aut Zaim M. Institut de Recherche Pierre Fabre, 31035, Toulouse, France aut Zetlaoui J. Nestlé Health Science SA, 1800, Vevey, Switzerland aut Vellas B. INSERM U1027, Toulouse, France aut The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 619-623 1279-7707 17:7<619 2013 17 12603 https://doi.org/10.1007/s12603-013-0350-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0350-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferry M. Nutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13, Paris, France aut NATIONALLICENCE 700 1- Coley N. INSERM U1027, Toulouse, France aut NATIONALLICENCE 700 1- Andrieu S. INSERM U1027, Toulouse, France aut NATIONALLICENCE 700 1- Bonhomme C. Lactalis Nutrition Santé, 35370, Torcé, France aut NATIONALLICENCE 700 1- Caubere J. Pierre Fabre, 81106, Castres, France aut NATIONALLICENCE 700 1- Cesari M. INSERM U1027, Toulouse, France aut NATIONALLICENCE 700 1- Gautry J. Nestlé Clinical Nutrition, 77446, Marne la Vallée, France aut NATIONALLICENCE 700 1- Garcia Sanchez I. DG Sanco, Brussels, Belgium aut NATIONALLICENCE 700 1- Hugonot L. MedForma, Paris, France aut NATIONALLICENCE 700 1- Mansuy L. Pierre Fabre, 81106, Castres, France aut NATIONALLICENCE 700 1- Pahor M. University of Floride, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Pariente J. Department of Neurology, Purpan Hospital, 31000, Toulouse, France aut NATIONALLICENCE 700 1- Ritz P. Nutrition Unit, Toulouse University Hospital, Toulouse, France aut NATIONALLICENCE 700 1- Salva A. Institut Català de l'Envelliment, Universita Autonoma de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Sijben J. Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition, 6700 CA, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- Wieggers R. Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition, 6700 CA, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- Ythier-Moury P. Sanofi R&D — TSU Aging, 34184, Montpellier, France aut NATIONALLICENCE 700 1- Zaim M. Institut de Recherche Pierre Fabre, 31035, Toulouse, France aut NATIONALLICENCE 700 1- Zetlaoui J. Nestlé Health Science SA, 1800, Vevey, Switzerland aut NATIONALLICENCE 700 1- Vellas B. INSERM U1027, Toulouse, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 619-623 1279-7707 17:7<619 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer