naa a22 4500 510786065 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12603-013-0043-6 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0043-6 Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke [Elektronische Daten] [K. Lau, Y. Chan, Y. Wong, K. Teo, K. Yiu, S. Liu, L. Li, X. Shu, S. Ho, K. Chan, C. Siu, Hung Tse] Objetives: To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS). Design: Cross-sectional study. Participants: 125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006. Measurements: Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects. Results: The mean age of the study population was 65.9±11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5±12.7g/day and 2.9±8.8g/day respectively. Their mean FMD was 2.6±2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1±2.1% versus 3.0±2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS. Conclusions: Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events. Serdi and Springer-Verlag France, 2013 Garlic nationallicence endothelial function nationallicence ischemic stroke nationallicence Lau K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Chan Y. Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Wong Y. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Teo K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Yiu K. Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut Liu S. Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Li L. Division of Rehabilitation Medicine, Department of Medicine, Tung Wah Hospital, The University of Hong Kong, Hong Kong SAR, China aut Shu X. Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University of Medicine, Nashville, USA aut Ho S. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Chan K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut Siu C. Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut Tse Hung Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 600-604 1279-7707 17:7<600 2013 17 12603 https://doi.org/10.1007/s12603-013-0043-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0043-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lau K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Chan Y. Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Wong Y. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Teo K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Yiu K. Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Liu S. Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Li L. Division of Rehabilitation Medicine, Department of Medicine, Tung Wah Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Shu X. Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University of Medicine, Nashville, USA aut NATIONALLICENCE 700 1- Ho S. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Chan K. Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Siu C. Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Tse Hung Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 600-604 1279-7707 17:7<600 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer