naa a22 4500 510786081 CHVBK 20180411083302.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12603-013-0362-7 doi (NATIONALLICENCE)springer-10.1007/s12603-013-0362-7 Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US task force recommendations [Elektronische Daten] [B. Vellas, M. Pahor, T. Manini, D. Rooks, J. Guralnik, J. Morley, S. Studenski, W. Evans, C. Asbrand, R. Fariello, S. Pereira, Y. Rolland, G. Abellan Van Kan, M. Cesari, W. Chumlea, R. Fielding] An international task force of academic and industry leaders in sarcopenia research met on December 5, 2012 in Orlando, Florida to develop guidelines for designing and executing randomized clinical trials of sarcopenia treatments. The Task Force reviewed results from previous trials in related disease areas to extract lessons relevant to future sarcopenia trials, including practical issues regarding the design and conduct of trials in elderly populations, the definition of appropriate target populations, and the selection of screening tools, outcome measures, and biomarkers. They discussed regulatory issues, the challenges posed by trials of different types of interventions, and the need for standardization and harmonization. The Task Force concluded with recommendations for advancing the field toward better clinical trials. Serdi and Springer-Verlag France, 2013 Sarcopenia nationallicence clinical trial nationallicence skeletal muscle nationallicence frailty nationallicence intervention nationallicence Vellas B. Inserm UMR1027 Inserm, Toulouse, France aut Pahor M. University of Florida, Gainesville, FL, USA aut Manini T. University of Florida, Gainesville, FL, USA aut Rooks D. Novartis Institutes for Biomedical Research, Cambridge, MA, USA aut Guralnik J. University of Maryland School of Medicine, Baltimore, MD, USA aut Morley J. St. Louis University Medical School, St. Louis, MO, USA aut Studenski S. University of Pittsburgh, Pittsburgh, PA, USA aut Evans W. GlaxoSmithKline, Research Triangle Park, Durham, NC, USA aut Asbrand C. Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany aut Fariello R. Neurotune AG, 8952, Schlieren, Switzerland aut Pereira S. Abbott Nutrition R&D, Columbus, OH, USA aut Rolland Y. Inserm UMR1027 Inserm, Toulouse, France aut Abellan Van Kan G. Gerontopole, Toulouse University Hospital, Toulouse, France aut Cesari M. Inserm UMR1027 Inserm, Toulouse, France aut Chumlea W. Lifespan Health Research Center, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA aut Fielding R. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 612-618 1279-7707 17:7<612 2013 17 12603 https://doi.org/10.1007/s12603-013-0362-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-013-0362-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vellas B. Inserm UMR1027 Inserm, Toulouse, France aut NATIONALLICENCE 700 1- Pahor M. University of Florida, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Manini T. University of Florida, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Rooks D. Novartis Institutes for Biomedical Research, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Guralnik J. University of Maryland School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Morley J. St. Louis University Medical School, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Studenski S. University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Evans W. GlaxoSmithKline, Research Triangle Park, Durham, NC, USA aut NATIONALLICENCE 700 1- Asbrand C. Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany aut NATIONALLICENCE 700 1- Fariello R. Neurotune AG, 8952, Schlieren, Switzerland aut NATIONALLICENCE 700 1- Pereira S. Abbott Nutrition R&D, Columbus, OH, USA aut NATIONALLICENCE 700 1- Rolland Y. Inserm UMR1027 Inserm, Toulouse, France aut NATIONALLICENCE 700 1- Abellan Van Kan G. Gerontopole, Toulouse University Hospital, Toulouse, France aut NATIONALLICENCE 700 1- Cesari M. Inserm UMR1027 Inserm, Toulouse, France aut NATIONALLICENCE 700 1- Chumlea W. Lifespan Health Research Center, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA aut NATIONALLICENCE 700 1- Fielding R. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer Paris 17/7(2013-08-01), 612-618 1279-7707 17:7<612 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer