naa a22 4500 510786170 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12603-012-0399-z doi (NATIONALLICENCE)springer-10.1007/s12603-012-0399-z Dietary nucleotides extend the life span in Sprague-Dawley rats [Elektronische Daten] [M. Xu, R. Liang, Q. Guo, S. Wang, M. Zhao, Z. Zhang, Junbo Wang, Yong Li] Background: Objective: To observe the effect of prolonged feeding of dietary nucleotides (NTs), and to clarify the effect of NTs on life extension of Sprague-Dawley rats. Methods: There were 50 Sprague-Dawley rats in each group (male:female ratio=1:1), which were fed diets supplemented with NTs at concentrations of 0%, 0.01%, 0.04%, 0.16% and 0.64% (wt/wt) from the age of 4 weeks until natural death. We investigated the moribundity and mortality, survival time, spontaneous tumor incidence, and serum oxidative status. Results: NTs have significantly influence body weight of first 3 month old and food consumption of male rats throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. NTs notably increased the mean life span, and the maximal life span. Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes. Conclusions: Long-term feeding of NTs could dose-dependently increase life span in Sprague-Dawley rats, especially, the tumor-bearing ones. Moreover, the antioxidative property of NTs may be responsible for the increased life span. Serdi and Springer-Verlag France, 2012 Dietary nucleotides nationallicence longevity nationallicence antioxidant ability nationallicence Sprague-Dawley rat nationallicence Xu M. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Liang R. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Guo Q. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Wang S. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Zhao M. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Zhang Z. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Wang Junbo Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut Li Yong Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 223-229 1279-7707 17:3<223 2013 17 12603 https://doi.org/10.1007/s12603-012-0399-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0399-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu M. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Liang R. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Guo Q. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Wang S. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Zhao M. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Zhang Z. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Wang Junbo Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 700 1- Li Yong Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 223-229 1279-7707 17:3<223 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer