naa a22 4500 510786189 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12603-012-0402-8 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0402-8 A review of multidomain interventions to support healthy cognitive ageing [Elektronische Daten] [N. Schneider, C. Yvon] Objective: The risk for cognitive decline and for developing Alzheimer's disease increases with age. The aetiology is assumed to be of multi-factorial origin, and treatment opportunities are lacking. Despite the multi-factorial origin, many intervention studies focused on single factors to influence cognitive health with inconsistent findings. In this view, more and more intervention studies aim to intervene on multiple factors simultaneously to affect or slow down cognitive decline. The purpose of this paper is to give an overview of these multidomain intervention trials. Methods: We conducted a non-systematic literature search in Medline, Scopus, Cochrane Library, and clinical trials databases up to October 2011 to review multidomain interventions that investigated effects of combined lifestyle-related factors on cognitive decline and the progression of dementia. Results: Interest in multidomain interventions increased over the past years. We identified six completed and published trials and eight ongoing or not yet published studies that investigated effects on cognitive outcomes. First completed trials yielded promising results for the combination of exercise and mental training and diet and behavioural weight management. Results of ongoing multidomain trials are awaited. Conclusions: Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. Larger high-quality randomized controlled trials are required to systematically investigate the cognitive effect of programs comprising physical and mental activity as well as nutritional aspects. Serdi and Springer-Verlag France, 2012 Healthy ageing nationallicence multidomain interventions nationallicence mental activity nationallicence physical activity nationallicence diet nationallicence Schneider N. Nestec Ltd., Nestlé Research Center Lausanne, Lausanne, Switzerland aut Yvon C. Nestec Ltd., Nestlé Research Center Lausanne, Lausanne, Switzerland aut The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 252-257 1279-7707 17:3<252 2013 17 12603 https://doi.org/10.1007/s12603-012-0402-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0402-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schneider N. Nestec Ltd., Nestlé Research Center Lausanne, Lausanne, Switzerland aut NATIONALLICENCE 700 1- Yvon C. Nestec Ltd., Nestlé Research Center Lausanne, Lausanne, Switzerland aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 252-257 1279-7707 17:3<252 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer