naa a22 4500 510786235 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12603-012-0394-4 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0394-4 Gait variability at fast-pace walking speed: A biomarker of mild cognitive impairment? [Elektronische Daten] [Olivier Beauchet, G. Allali, C. Launay, F. Herrmann, C. Annweiler] Background: The interpretation of the increase in stride-to-stride variability of stride time (STV) regarding the evolution of cognitive deficits across the dementia spectrum is matter of debate. Objective: The aim of this study was to compare STV at usual and fast-pace walking speeds of MCI patients with that of cognitively healthy individuals (CHI) and Alzheimer's disease (AD) patients with mild dementia, while considering the effects of potential confounders. Methods: STV while walking at usual and fast-pace walking speeds was recorded with the GAITRite® system from 116 older adults (mean age 75.6±6.5 years; 55.2% female) divided into 3 groups according to their cognitive status (44 CHI, 39 MCI patients and 33 AD patients with mild dementia). Results: The full adjusted multiple linear regression models showed that high STV was associated with slow gait speed at usual-pace walking speed (P=0.002) and with the MCI status at fast-pace walking speed (P=0.015). Conclusions: High STV at fast-pace walking speed was a specific gait disturbance of MCI patients in the sample of studied participants, and thus could be used in the future as a specific biomarker of MCI patients. Serdi and Springer-Verlag France, 2012 Alzheimer's disease nationallicence mild cognitive impairment nationallicence gait disorders nationallicence stride-to-stride variability of stride time nationallicence Beauchet Olivier Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut Allali G. Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland aut Launay C. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut Herrmann F. Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland aut Annweiler C. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 235-239 1279-7707 17:3<235 2013 17 12603 https://doi.org/10.1007/s12603-012-0394-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0394-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beauchet Olivier Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut NATIONALLICENCE 700 1- Allali G. Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland aut NATIONALLICENCE 700 1- Launay C. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut NATIONALLICENCE 700 1- Herrmann F. Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland aut NATIONALLICENCE 700 1- Annweiler C. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 235-239 1279-7707 17:3<235 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer