naa a22 4500 510786243 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12603-012-0095-z doi (NATIONALLICENCE)springer-10.1007/s12603-012-0095-z Biomarkers of oxidative stress in patients with wet age related macular degeneration [Elektronische Daten] [P. Zafrilla, M. Losada, A. Perez, G. Caravaca, J. Mulero] Objective: The aim of this study was to analyze biomarkers of oxidative stress in patients with wet age related macular degeneration (AMD). Participants and Measurements: Case-control study that includes 163 patients with wet AMD (age group of 55-82 years with the mean age of 71 years and 170 age-matched healthy controls in the age group of 55-78 years with the mean age of 71 years. The following parameters were determined: reduced and oxidized Glutathione (GSH/GSSH), protein carbonyl groups, total antioxidant activity in plasma and the activity of endogenous antioxidant enzymes, such as, gluthatione peroxidase, gluthatione reductase and superoxide dismutase. Results: We observed total antioxidant activity higher in control group (CG) compared with patients with wet AMD (7.1 ± 1.2 μM Trolox vs 5.8 ± 1.1 μM Trolox). Values of superoxide dismutase activity (SOD), gluthatione reductase (GR) and gluthatione peroxidase (GPx) are higher in control group than in patients with wet AMD. According to the GSH/GSSH results, average values were higher in the CG than in patients with wet AMD and data were not significantly different.. Values of protein carbonyl groups were higher in patients with wet AMD than in CG and significant differences were found. Conclusions: The finding of the present study suggests that the patients with wet AMD are an altered metabolic state of oxidation-reduction and that it is convenient to give therapeutic interventions with antioxidants. We have demonstrated that systematic oxidative stress, measured by different biomarkers is closely associated with the wet AMD. Serdi and Springer Verlag France, 2012 Protein carbonyl groups nationallicence GSH/GSSH nationallicence age related macular degeneration (ARMD) nationallicence antioxidant enzymes nationallicence Zafrilla P. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut Losada M. University Hospital Jose Ma Morales Meseguer, Murcia, Spain aut Perez A. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut Caravaca G. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut Mulero J. University Hospital Jose Ma Morales Meseguer, Murcia, Spain aut The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 219-222 1279-7707 17:3<219 2013 17 12603 https://doi.org/10.1007/s12603-012-0095-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0095-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zafrilla P. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut NATIONALLICENCE 700 1- Losada M. University Hospital Jose Ma Morales Meseguer, Murcia, Spain aut NATIONALLICENCE 700 1- Perez A. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut NATIONALLICENCE 700 1- Caravaca G. Department of Food Technology and Nutrition, Catholic University of San Antonio, 30107, Murcia, Spain aut NATIONALLICENCE 700 1- Mulero J. University Hospital Jose Ma Morales Meseguer, Murcia, Spain aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 219-222 1279-7707 17:3<219 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer