naa a22 4500 510786251 CHVBK 20180411083303.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12603-012-0376-6 doi (NATIONALLICENCE)springer-10.1007/s12603-012-0376-6 Selenium is inversely associated with interleukin-6 in the elderly [Elektronische Daten] [C. Tseng, C. Ho, H. Hsu, C. Lin, C. Li, T. Li, C. Liu, C. Lin, Wen-Yuan Lin] Background: Selenium is an essential trace element with antioxidant property. Decreased serum selenium concentration with aging had been found in previous report. In this study, we aim to investigate the association between serum selenium and the inflammatory cytokine interleukin-6 in the elderly living in long-term care facilities in Taiwan. Materials and Methods: A total of 336 subjects aged 65 years and older (range of age: 65-101 years) were recruited from eight long-term care facilities in 2002-2003. Baseline characteristics, anthropometric indices, and biochemical data were obtained. Selenium deficiency was defined as serum selenium concentration < 80 μg/L. Multiple logistic and linear regression analyses were used to examine the relationships between selenium deficiency and interleukin-6 (divided into quartiles). Results: The prevalence of selenium deficiency was 35.6% in men and 43.2% in women, respectively. After adjusting for potential confounders using multiple logistic regression analysis, interleukin-6 quartiles were significantly associated with selenium deficiency. Compared to the interleukin-6 quartile I, the adjusted odds ratios of having selenium deficiency for interleukin-6 quartile II, III, IV were 1.00(0.50∼2.01), 1.24 (0.62∼2.50), and 2.35(1.15‖4.83), respectively. The increasing odds ratios for selenium deficiency in higher interleukin-6 quartiles revealed dose-response effects (p < 0.05). Moreover, multiple linear regression analysis showed that serum selenium was significantly inversely associated with interleukin-6 after adjusting for potential confounders. Conclusions: Serum selenium was inversely associated with inflammatory cytokine interleukin-6 among elderly living in long-term care facilities in Taiwan. Monitoring serum selenium should be considered in these institutionalized elderly. Serdi and Springer-Verlag France, 2012 Selenium nationallicence interleukin-6 nationallicence elderly nationallicence long-term care nationallicence Taiwan nationallicence Tseng C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut Ho C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut Hsu H. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut Lin C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut Li C. Medical Research, China Medical University Hospital, Taichung, Taiwan aut Li T. Medical Research, China Medical University Hospital, Taichung, Taiwan aut Liu C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut Lin Wen-Yuan Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 280-284 1279-7707 17:3<280 2013 17 12603 https://doi.org/10.1007/s12603-012-0376-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12603-012-0376-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tseng C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Ho C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Hsu H. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Lin C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Li C. Medical Research, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Li T. Medical Research, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Liu C. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Lin Wen-Yuan Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 773 0- The journal of nutrition, health & aging Springer-Verlag 17/3(2013-03-01), 280-284 1279-7707 17:3<280 2013 17 12603 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer